Evidence map›Paper›PMID 41244218›Full record

ArticleCerebral circulation - cognition and behavior2025

Subclinical vascular risk composites and dementia imaging biomarkers 17-20 years later in the Multi-Ethnic Study of Atherosclerosis (MESA).

Marc D Rudolph, Jordan Tanley, Jingzhong Ding, Kiran K Solingapuram Sai, Haiying Chen, Kathleen M Hayden, Yongmei Liu, R Nick Bryan, Ilya M Nasrallah, Sudipto Dolui and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marc D RudolphDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jordan TanleyDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jingzhong DingDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Kiran K Solingapuram SaiDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Haiying ChenDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Yongmei LiuDepartment of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27701, USA.
R Nick BryanNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Ilya M NasrallahDepartment of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Sudipto DoluiDepartment of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Mohamad HabesNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
José A LuchsingerDepartments of Medicine and Epidemiology, Columbia University Irving Medical Center, NY, NY, USA.
Robert A KoeppeUniversity of Michigan, Ann Arbor, MI, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Suzanne CraftDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Samuel N LockhartDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Timothy M HughesDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Funding

Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Multi-Ethnic Study of Atherosclerosis- Cellular Exosomes in Neurodegeneration and Dementia (MESA-CEND)R01AG068629 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN, HUGHES, TIMOTHY M. · 2024 to 2025
$1.5M
NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG058969NIA NIH HHS R01 AG068629
6 · The paper itself

Abstract

Cardiovascular disease (CVD) risk factors captured in midlife represent potentially modifiable features of CVD, stroke, dementia, and dementia-related neuropathology and are included in dementia risk scores.

Indexed as

MRIPathwaysPETRisk factorsVascular

Identifiers

PMID41244218
PMCPMC12617641

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.