ArticleRegenerative therapy2025
Regenerative effects of PRP-impregnated collagen-gelatin sponge in a full-thickness skin defect model.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Two-stage reconstruction using basic fibroblast growth factor-impregnated artificial dermis and acellular fish skin graft in a dog with distal extremity soft tissue sarcoma.The Journal of veterinary medical science · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Artificial dermis is an essential biomaterial for reconstructing full-thickness skin defects. Pelnac G Plus® is a collagen-gelatin sponge (CGS) that can be impregnated with basic fibroblast growth factor (bFGF), offering sustained release and proven clinical efficacy. However, the off-label use of bFGF by impregnation remains restricted under current pharmaceutical regulations in Japan. In this study, we evaluated the wound healing potential of autologous platelet-rich plasma (PRP) as an alternative bioactive substance when impregnated into CGS. Methods: Full-thickness skin defect models were created in nude rats and treated with artificial dermis alone (CGS group), artificial dermis + PRP (CGS + PRP group), or artificial dermis + bFGF (CGS + FGF group). Results: On postoperative day 14, the CGS + PRP group exhibited significantly greater collagen thickness and vascular density than the CGS group. Furthermore, the CGS + PRP group showed a smaller wound area than the CGS + FGF group Conclusions: Our findings demonstrate that bFGF and PRP exert distinct effects on wound healing in a secondary-intention model. bFGF effectively promoted dermis-like granulation tissue regeneration without accelerating contraction, supporting its use in anatomical sites where scar contracture must be avoided. In contrast, PRP enhanced wound contraction and ulcer area reduction, suggesting clinical utility in non-healing ulcers where delayed secondary healing is a major concern.
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