ArticleBiochemistry and biophysics reports2025
Cardiac, reproductive, and brain toxicity of zinc oxide nanoparticles in male rats: Focus on morphological alterations and oxidative stress markers.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Zinc Oxide Nanoparticles' Acute and Subacute Oral Toxic Effects on Pancreas in Adult Male Albino Rats.Journal of applied toxicology : JAT · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our bodies are exposed to different types of nanoparticles in our daily routine. Hence, this experiment aimed to measure the effects of different doses of zinc oxide nanoparticles (ZnO NPs) on various organs in Wistar rats. Wistar rats were randomly divided into 6 groups as follows: group 1: control, group 2: control rats +5 mg/kg ZnO NPs, group 3: control rats +10 mg/kg ZnO NPs, group 4: control rats +25 mg/kg ZnO NPs, group 5: control rats +50 mg/kg ZnO NPs, and group 6: control rats +100 mg/kg ZnO NPs. The ZnO NPs were administrated orally for one month, and then the heart, hippocampus, and testis were removed and used for more analysis. The malondialdehyde (MDA) levels, total oxidant status (TOS), and total antioxidant capacity (TAC) were measured. For histological analysis, the tissues were analyzed by hematoxylin-eosin staining. TAC significantly decreased in the hippocampus, heart, and testis of rats treated with 10-100 mg/kg ZnO NPs compared to the control (P < 0.05). The TOS and MDA levels significantly increased by 25-100 mg/kg ZnO NPs compared to the control (P < 0.05). Histological findings show that the structure of the hippocampus, heart, and tissues in the rats received 5 was similar to the healthy control rats. While, 25-100 mg/kg ZnO NPs had harmful effects on these tissues. Our findings show that high dosages of ZnO NPs induce oxidative stress and histopathological changes in the hippocampus, heart, and testis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.