ArticleAmerican journal of cancer research2025
Factors influencing imaging and functional recovery outcomes after limb-salvage surgery in patients with bone tumors: a retrospective case-control study.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimb-salvage surgery is the preferred treatment for primary bone tumors, yet postoperative imaging and functional outcomes remain variable. This study aims to identify factors affecting postoperative imaging and functional recovery outcomes in patients undergoing limb-salvage surgery for primary bone tumors.
methodsA retrospective case-control study was conducted on 231 adult patients with primary bone tumors who underwent limb-salvage surgery at a single institution between January 2016 and January 2024. Patients were categorized into favorable and adverse outcome groups based on postoperative imaging, local recurrence, and Musculoskeletal Tumor Society scores. Data were collected on demographics, tumor characteristics, surgical methods, nutritional status, adjuvant treatments, supportive care, and complications. Univariate and multivariate logistic regression analyses were performed to identify factors independently associated with favorable outcomes.
resultsSignificant differences were found between outcome groups in age, lymphocyte count, preoperative chemotherapy, tumor margin clarity, tumor size, resection method, adjuvant treatment, rehabilitation, and infection rates. Patients with favorable outcomes were younger, had higher lymphocyte counts and albumin levels, received more preoperative chemotherapy and adjuvant treatments, displayed clearer tumor margins, underwent wide resection more often, had smaller tumors, and participated more in rehabilitation. The adverse group had higher rates of infection and marginal resections. No significant differences were observed in tumor type, location, reconstruction method, prealbumin and hemoglobin levels, or rates of pain management, psychological support, delayed wound healing, joint stiffness, or muscle atrophy. Multivariate analysis identified younger age, wide resection, and adjuvant treatment as independent predictors of favorable imaging and functional recovery.
conclusionYounger age, wide surgical resection, and receipt of adjuvant treatment independently predict improved postoperative imaging and functional outcomes following limb-salvage surgery for primary bone tumors. Optimizing perioperative management and surgical strategies may enhance patient recovery and long-term outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.