ArticleBioMed research international2025
The LBX2-AS1-miR-491-5p-PKM2 Positive Feedback Loop Promotes Radiation Resistance of Esophageal Cancer by Enhancing Glycolysis.
Article in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The LBX2-AS1-miR-491-5p-PKM2 Positive Feedback Loop Promotes Radiation Resistance of Esophageal Cancer by Enhancing Glycolysis.BioMed research international · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Radioresistance is a significant factor affecting the therapeutic efficacy of radiotherapy. This study is aimed at investigating the molecular mechanism by which LBX2-AS1 regulates pyruvate kinase M2 (PKM2) to influence radioresistance and its potential as a biomarker for radioresistance in esophageal cancer. Methods and Key Findings: Radioresistant sub-cell lines, KYSE150R, were established in KYSE150 cells, and PKM2, cyclin D1, HIF-1 Conclusion and Clinical Implications: LBX2-AS1-miR-491-5p-PKM2 positive feedback loop enhances the radioresistance of esophageal cancer cells by altering the cell cycle and enhancing glycolysis. High level of LBX2-AS1 in serum was correlated with worse DCR, lymphatic metastasis, worse overall survival, and progression-free survival.
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