Evidence map›Paper›PMID 41244070›Full record

ArticleBioMed research international2025

Overexpression of

Mahdieh Hashemi, Mahdi Hesaraki, Roya Ramezankhani, Seyyed Mohammad Yaghoubi, Bahare Shokouhian, Abbas Piryaei, Elham Rismani, Mustapha Najimi, Massoud Vosough

Abstract read
In one paragraph

Article in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Overexpression ofBioMed research international · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahdieh HashemiDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran, royaninstitute.org.ORCID https://orcid.org/0009-0004-6772-5273
Mahdi HesarakiDepartment of Regeneration Medicine in Wound Healing, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran.ORCID https://orcid.org/0000-0001-7082-2446
Roya RamezankhaniDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran, royaninstitute.org.ORCID https://orcid.org/0000-0001-6812-9853
Seyyed Mohammad YaghoubiImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, tbzmed.ac.ir.ORCID https://orcid.org/0009-0006-3423-5336
Bahare ShokouhianDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran, royaninstitute.org.ORCID https://orcid.org/0000-0002-1625-8626
Abbas PiryaeiDepartment of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, sbmu.ac.ir.ORCID https://orcid.org/0000-0002-3182-6214
Elham RismaniMolecular Medicine Department, Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran, pasteur.ac.ir.ORCID https://orcid.org/0000-0001-9997-3512
Mustapha NajimiLaboratory of Pediatric Hepatology and Cell Therapy, Institute of Experimental and Clinical Research (IREC), UCLouvain, Brussels, Belgium.ORCID https://orcid.org/0000-0002-7329-9635
Massoud VosoughDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran, royaninstitute.org.ORCID https://orcid.org/0000-0001-5924-4366

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Despite the remarkable advances in approved therapeutic approaches, the recurrence rate of hepatocellular carcinoma (HCC) is very high after treatment. Therefore, introducing innovative therapeutic modalities such as targeted molecular therapies is inevitable. Lysine demethylase 6A ( Method: A lentiviral-based vector was used to induce Results: Conclusion: Overexpression of

Indexed as

Carcinoma, HepatocellularCell DifferentiationHepatocytesHistone DemethylasesLiver NeoplasmsCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansHistone DemethylasesKDM6A protein, humancancerous phenotypedifferentiation therapyhepatocellular carcinomaKDM6Alentivirus vector

Identifiers

PMID41244070
PMCPMC12619137

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.