ReviewJournal of inflammation research2025
The Role of Fibroblasts in Atopic Dermatitis: Establishing Proinflammatory Microenvironments and Mediating Cellular Crosstalk.
Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Age-related changes of FCGR3AEBioMedicine · 2026Article
- Single-cell transcriptomics reveals epithelial-stromal crosstalk underlying fibrotic remodeling in frontal fibrosing alopecia.iScience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atopic dermatitis (AD) is a chronic inflammatory dermatosis characterized by skin barrier dysfunction and dysregulation of the immune system. Previous studies have primarily focused on the roles of immune cells and keratinocytes (KCs) in AD. Fibroblasts (FBs) are stromal cells that produce extracellular matrix (ECM) and maintain its homeostasis. However, recent studies indicate that FBs can secrete cytokines and other mediators, thereby actively contributing to immune regulation and the propagation of inflammation. Furthermore, advances in single-cell RNA sequencing and spatial transcriptomics have highlighted the extensive crosstalk involving FBs in AD. In this review, we summarize previously reported evidence regarding the role of FBs in AD to provide a deeper understanding of the pathogenic mechanisms underlying the disease and to suggest new therapeutic for strategies patients, particularly those with inadequate responses to conventional treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.