Evidence map›Paper›PMID 41243981›Full record

ArticleNucleic acids research2026

African Natural Products Database (ANPDB): A resource for exploring the therapeutic potential of natural compounds from Africa.

Jude Y Betow, Ammar Qaseem, Boris D Bekono, Yue Feng, Aurélien F A Moumbock, Conrad V Simoben, Smith B Babiaka, Solange A Tanyi, Vanessa A Shu, Ariane T Ndi and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Jude Y BetowCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0004-5503-8281
Ammar QaseemInstitute of Pharmaceutical Sciences, Research Group Pharmaceutical Bioinformatics, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Strasse 9, 79104 Freiburg, Germany.ORCID 0000-0002-2956-5086
Boris D BekonoCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0003-1077-4176
Yue FengInstitute of Pharmaceutical Sciences, Research Group Pharmaceutical Bioinformatics, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Strasse 9, 79104 Freiburg, Germany.ORCID 0009-0006-0637-4646
Aurélien F A MoumbockInstitute of Pharmaceutical Sciences, Research Group Pharmaceutical Bioinformatics, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Strasse 9, 79104 Freiburg, Germany.ORCID 0000-0002-6034-2016
Conrad V SimobenStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.ORCID 0000-0002-5958-6961
Smith B BabiakaDepartment of Chemistry, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0002-4476-5860
Solange A TanyiCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0006-7576-7654
Vanessa A ShuDepartment of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck Str. 4, Halle (Saale) 06120, Germany.ORCID 0009-0002-8064-6145
Ariane T NdiCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0001-9465-271X
Pascal Amoa OnguénéCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0003-2919-6089
Clovis S MetugeCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0002-5710-6354
Simeon AkameDepartment of Clinical Microbiology, Faculty of Health Sciences, University of Buea, Buea CM00237, Cameroon.ORCID 0000-0002-3400-8874
Donatus B EniCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0002-4148-6372
Cyril T Namba-NzanguimCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0002-8404-7214
Mathieu J M TjegbeCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0006-0615-0335
Marianka N L DikandeCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0005-0664-7133
Patience T AkehCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0002-0297-934X
Sounders BalgahCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0003-7905-7519
Cyprian D MehCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0008-2883-752X
Akachukwu IbezimDepartment of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001  Nsukka, Nigeria.ORCID 0000-0003-1620-5716
Idris F TabiCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0004-3297-0260
Yvette I MalangeCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0002-7621-0816
Bakoh NdingkokharCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0002-8011-6585
Leonel E NjumeCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0009-0000-6961-974X
Kiran K TelukuntaTarunavadaanenasaha Muktbharatonnayana Samstha Foundation, 500026  Hyderabad, India.ORCID 0000-0002-3219-9240
Said AmraniDepartment of Biology, Faculté des Sciences Biologiques - USTHB, 16111  Algiers, Algeria.ORCID 0000-0002-7384-1498
Oyere T EbobDepartment of Chemistry and Forensics, School of Science and Technology (SST), Nottingham Trent University, NG1 4FQ  Nottingham, UK.ORCID 0000-0002-2373-1354
Wolfgang SipplDepartment of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck Str. 4, Halle (Saale) 06120, Germany.ORCID 0000-0002-5985-9261
Stefan GüntherInstitute of Pharmaceutical Sciences, Research Group Pharmaceutical Bioinformatics, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Strasse 9, 79104 Freiburg, Germany.ORCID 0000-0003-3744-189X
Fidele Ntie-KangCenter for Drug Discovery, University of Buea, P.O. Box 63, Buea CM-00237, Cameroon.ORCID 0000-0003-0795-394X

Funding

Alexander von Humboldt Foundation 4-1156361-CMR-IPChina Scholarship Council 202308080095Gates Foundation INV-036848Gates Foundation INV-055897LifeArc 10 646
6 · The paper itself

Abstract

The African Natural Products Database (ANPDB) is a comprehensive repository currently encompassing over 11 000 natural compounds sourced from diverse species across the African continent. ANPDB integrates both experimental and predicted NMR and MS data to enhance compound annotation and facilitate dereplication, utilizing machine learning algorithms for spectral simulation and fragment prediction. The database offers a range of methods for compound structure search, including substructure matching, chemical similarity analysis, and property-based filtering, empowering users to efficiently explore chemical diversity. ANPDB also compiles detailed metadata on the traditional medicinal uses of source organisms, linking ethnobotanical knowledge with chemical and biological data. By consolidating information on biological sources, bioactivities, traditional applications, and bibliographic references (currently ranging from 1961 to 2024), ANPDB provides a robust platform for drug discovery, natural products research, and the exploration of Africa's unique chemical and medicinal biodiversity. The database is open access, and the entire dataset and metadata are available for download and for computer-aided drug design endeavours. Link to the website: https://african-compounds.org.

Indexed as

Biological ProductsDatabases, ChemicalDatabases, FactualDrug DiscoveryAfricaHumansBiological Products

Identifiers

PMID41243981
PMCPMC12807775

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.