Evidence map›Paper›PMID 41243868›Full record

Trial reportClinical transplantation2025

Organ Donor Potential After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest: A Post-Hoc Analysis of a Randomized Controlled Trial.

Hanne C R Verberght, Thijs S R Delnoij, Martje M Suverein, Jody Lunsing, Renicus C Hermanides, Luuk Otterspoor, Carlos V Elzo Kraemer, Alexander P J Vlaar, Joris J van der Heijden, Erik Scholten and 21 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03101787 (Early Initiation of Extracorporeal Life Support in Refractory OHCA), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03101787 nacompletednot on this map

Early Initiation of Extracorporeal Life Support in Refractory OHCA (INCEPTION)

TypeinterventionalSponsorMaastricht University Medical CenterRan2017 to 2022Enrolled134ConditionsCardiac Arrest, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac DeathArmsExtracorporeal cardiopulmonary resuscitation (ECPR)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Hanne C R VerberghtDepartment of Surgery, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0003-4471-6361
Thijs S R DelnoijDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0003-2427-7613
Martje M SuvereinDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0003-3308-0492
Jody LunsingDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.
Renicus C HermanidesDepartment of Cardiology, Isala Clinics, Zwolle, the Netherlands.ORCID https://orcid.org/0000-0003-3931-2565
Luuk OtterspoorDepartment of Intensive Care, Catharina Hospital, Eindhoven, the Netherlands.ORCID https://orcid.org/0000-0002-8510-8648
Carlos V Elzo KraemerDepartment of Intensive Care, Leiden University Medical Center, Leiden University, Leiden, the Netherlands.ORCID https://orcid.org/0000-0002-5426-9334
Alexander P J VlaarDepartment of Intensive Care, Amsterdam University Medical Center location AMC, University, Amsterdam, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-3453-7186
Joris J van der HeijdenDepartment of Intensive Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-1730-3521
Erik ScholtenDepartment of Intensive Care, St. Antonius Hospital, Nieuwegein, the Netherlands.ORCID https://orcid.org/0000-0002-6403-9524
Corstiaan A den UilDepartment of Intensive Care Medicine, Maasstad Hospital, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-0635-2843
Dinis Dos Reis MirandaDepartment of Intensive Care, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0002-4329-7567
Sakir AkinDepartment of Intensive Care, Haga Hospital, The Hague, the Netherlands.ORCID https://orcid.org/0000-0003-0700-1930
Jesse de MetzDepartment of Intensive Care, OLVG, Amsterdam, the Netherlands.ORCID https://orcid.org/0009-0002-2575-694X
Iwan C C van der HorstDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0003-3891-8522
Bas J MathotDepartment of Pulmonary Medicine, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0002-4196-6421
Jeroen de JongeDepartment of Surgery, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0002-1131-027X
Mijntje W N NijboerDepartment of Surgery, Leiden University Medical Center, Leiden University, Leiden, the Netherlands.
Vincent E de MeijerDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-7900-5917
Jan S F SandersDepartment of Nephrology, University Medical Center Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-0904-3969
Maarten H L ChristiaansDepartment of Internal Medicine, Division of Nephrology, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0003-3558-2277
Arjan D van ZuilenDepartment of Nephrology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-2561-5533
Hanneke HagenaarsOrgan Donation Coordinator, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands.
Jentina WindOrgan Donation Coordinator, Maastricht University Medical Centre, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0002-6816-0268
Miranda DanhofOrgan Donation Coordinator, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Steven W M Olde DaminkDepartment of Surgery, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0002-5202-9345
Bjorn WinkensDepartment of Methodology & Statistics, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0002-6747-6228
Jos G MaessenDepartment of Cardiothoracic Surgery, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0003-3230-7712
Roberto LorussoCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0002-1777-2045
Marcel C G van de PollDepartment of Surgery, Maastricht University Medical Center+, Maastricht University, Maastricht, the Netherlands.ORCID https://orcid.org/0000-0002-3302-4063
INCEPTION‐investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtracorporeal cardiopulmonary resuscitation (ECPR) is a potentially life-saving intervention in refractory out-of-hospital cardiac arrest (OHCA). ECPR enables, in most of the treated cases, ICU admission to patients who otherwise would have died at the emergency department (ED). Still, many of them die, frequently after withdrawal of life-sustaining therapies due to irreversible critical conditions and related complications. The additional time provided by ECPR, however, might allow for the assessment of organ donor suitability. The aim of this study was to evaluate the impact of ECPR on the number of potential organ donors after refractory OHCA.

methodsWe performed a post-hoc analysis of the multicenter INCEPTION trial, which randomized 134 OHCA patients between conventional CPR (CCPR) and ECPR. Detailed patient reports were presented to transplant physicians to determine the acceptability of the liver and kidneys for organ donation. In addition to the intention to treat analysis, we performed an "as-treated" analysis, limited to patients arriving without return of spontaneous circulation (ROSC) at the ED.

resultsOut of 70 patients randomized to ECPR and 64 to CCPR, potential organ donors were identified in 14 (20%) and 4 (6%) patients, respectively (χ

conclusionAlthough ECPR is currently used with life-saving intentions, it may simultaneously increase the number of potential organ donors following cardiac arrest in selected patients.

trial registrationClinicalTrials.gov identifier: NCT03101787.

Indexed as

Cardiopulmonary ResuscitationExtracorporeal Membrane OxygenationLiver TransplantationOut-of-Hospital Cardiac ArrestTissue and Organ ProcurementTissue DonorsAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisextracorporeal cardiopulmonary resuscitationorgan donationout‐of‐hospital cardiac arrest

Identifiers

PMID41243868
PMCPMC12621156

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.