Trial reportNeuropsychopharmacology reports2025
The Effectiveness of Herbal Mixture of Echium amoenum L. and Rheum ribes on Obsessive-Compulsive Disorder: A Randomized Controlled Triple-Blind Clinical Trial.
Trial report in Neuropsychopharmacology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Effectiveness of Herbal Mixture of Echium amoenum L. and Rheum ribes on Obsessive-Compulsive Disorder: A Randomized Controlled Triple-Blind Clinical Trial.Neuropsychopharmacology reports · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveThe use of complementary and alternative medicine has gained traction in the treatment of psychiatric disorders, including obsessive-compulsive disorder (OCD). This trial investigates the efficacy of an herbal combination of Echium amoenum L. and Rheum ribes in reducing OCD symptoms.
methodsIn this triple-blind, randomized, controlled clinical trial, 40 participants were assigned to either the intervention group, receiving a daily dose of 30 mL of the herbal syrup, or a control group receiving a placebo. OCD severity was measured using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) at baseline, and at 4, 6, and 8 weeks. Side effects were monitored based on a preestablished checklist. Data were analyzed using SPSS v 16.
resultsThere was no significant difference between groups in age (p = 0.214) and sex (p = 1.00). The change in OCD scores between times significantly differed in the intervention group (p = 0.037). However, the OCD score did not change significantly during the time in the control group (p = 0.932). Moreover, there was no significant difference between the two groups at each time. However, the trend of changes during the trial was significant between the groups (p < 0.001). Additionally, no adverse effects were reported among participants consuming the herbal syrup.
conclusionThis study provides evidence that Echium amoenum L. and Rheum ribes can effectively decrease OCD severity without adverse effects, suggesting their potential as a safe treatment option. Future research with larger sample sizes and longer follow-up periods is warranted to confirm these findings and explore the mechanisms of action.
trial registrationIranian Registry for Clinical Trials (registration number: IRCT20200712048088N1).
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