ArticleArtificial organs2026
Hydraulic In Vitro Characterization of MR-Conditional Blood Pumps.
Article in Artificial organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cerebral Hemodynamic Changes During Cardiac Surgery: A Feasibility MR Study in Piglets.NMR in biomedicine · 2026Article
- Establishment of an MR-Conditional Porcine Model for Real-Time Assessment of Cerebral Blood Flow During Extracorporeal Circulation.Journal of cardiovascular development and disease · 2026Article
- PreliminaryFrontiers in medical technology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundMany cardiac surgical procedures use cardiopulmonary bypass (CPB), which in neonates requires the heart-lung machine (HLM) to be positioned close to the patient due to their small circulating blood volume. The absence of an MR-compatible blood pump to be used in CPB remains a key challenge for studying perioperative brain injury mechanisms in this high-risk group. This study aims to take the first step toward MR-conditional HLMs by developing hardware, verifying pump hydraulics, and ensuring MR compatibility.
methodsThis study presents three MR-conditional blood pump prototypes: a roller pump, a non-occlusive roller pump, and a centrifugal pump. MR compatibility was assessed by monitoring for imaging interference during scanning. Hydraulic performance was evaluated with pressure-flow diagrams using a mock circulation test bench.
resultsNone of the prototypes interfered with MR imaging, and although SNR was reduced by -8.43% ± 7.96%, image quality remained sufficient for reliable assessment of relevant brain regions. Roller and non-occlusive pumps maintained stable flow across pressure heads, with reductions of -4.46 ± 8.02 and -119.33 ± 18.22 mL/min, respectively. The centrifugal pump exhibited pressure-dependent performance (slope -2.21 ± 0.45 mmHg/[L/min]). All pumps generated non-pulsatile flow (SHE < 1000 erg/cm
conclusionAll three pumps meet basic MR-conditionality and flow requirements, supporting their potential for use in MRI-guided studies during neonatal cardiac surgery.
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