ArticleGeriatrics & gerontology international2025
Exploring Fall-Related Fracture Risk by Possible Fall-Risk Increasing Drugs in Japanese Older Adults Using Municipal Linked Medical and Long-Term Care Claim Data: A Nested Case-Control and Case-Crossover Study.
Article in Geriatrics & gerontology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
aimWe examined the association between the use of fall-risk-increasing drugs (FRIDs) and other medications, and the risk of fall-related fractures in Japanese community-dwelling older adults.
methodsWe used linked medical and long-term care insurance claims data from Tsukuba City, Japan (2014-2019). Two designs were applied: a nested case-control study comparing 1957 fracture cases to 7828 matched controls for long term use, and a case-crossover (CCO) study for short term use including 1840 fracture cases with up to 180 days of follow-up, in which the case period (1-30 days prior to the index date) was compared with control periods (five 30-day periods up to 180 days prior). Medication exposure included FRIDs and other medications. The outcome was non-vertebral fractures defined by diagnostic codes, imaging, and surgical or procedural treatment. Conditional logistic regression was used to calculate odds ratios (ORs).
resultsIn the nested case-control study, the adjusted ORs (fracture cases vs. controls) for use of calcium channel blockers (1.16, 95% confidence interval [CI]: 1.05-1.33) and other anti-dementia drugs (1.62, 95% CI: 1.11-2.37) were significantly elevated. In the CCO study, the unadjusted ORs (case period vs. control periods) for antipsychotics (3.65, 95% CI: 1.78-7.49), opioids (1.53, 95% CI: 1.05-2.22), anticonvulsants (1.86, 95% CI: 1.15-2.99), and NSAIDs (1.46, 95% CI: 1.18-1.71) were significantly elevated.
conclusionLong- and short-term use of specific medications is associated with increased fracture risk in older adults. Therefore, attention should be paid to prescription of these drugs in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.