Evidence map›Paper›PMID 41243558›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

High-Affinity Peptide-Drug Conjugate Ligands for the TRIM24 PHD and Bromodomain.

Michael A Platt, Ekaterina Kot, Louise A W Martin, Antoine L D Wallabrègue, Liwen Song, Alistair M Boyd, Lizbé Koekemoer, Ester M Hammond, Stuart J Conway

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael A PlattDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K.ORCID https://orcid.org/0000-0002-9760-0509
Ekaterina KotCentre for Medicines Discovery, University of Oxford, Nuffield Department of Medicine Research Building, Roosevelt Drive, Oxford, OX3 7FZ, U.K.
Louise A W MartinDepartment of Oncology, University of Oxford, Nuffield Department of Medicine Research Building, Roosevelt Drive, Oxford, OX3 7FZ, U.K.
Antoine L D WallabrègueDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K.
Liwen SongDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K.ORCID https://orcid.org/0009-0008-2532-8199
Alistair M BoydDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K.
Lizbé KoekemoerCentre for Medicines Discovery, University of Oxford, Nuffield Department of Medicine Research Building, Roosevelt Drive, Oxford, OX3 7FZ, U.K.
Ester M HammondDepartment of Oncology, University of Oxford, Nuffield Department of Medicine Research Building, Roosevelt Drive, Oxford, OX3 7FZ, U.K.
Stuart J ConwayDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K.ORCID https://orcid.org/0000-0002-5148-117X

Funding

Biotechnology and Biological Sciences Research Council BB/T008784/1
6 · The paper itself

Abstract

TRIM24 is an epigenetic transcriptional coregulator that "reads" KMe

Indexed as

Carrier ProteinsPeptidesAntineoplastic AgentsBreast NeoplasmsCell Line, TumorCell ProliferationHistonesHumansLigandsProtein BindingProtein DomainsTranscription FactorsAntineoplastic AgentsCarrier ProteinsHistonesLigandsPeptidesTranscription FactorsTRIM24 protein, humanbromodomainspeptide‐drug conjugatespeptidomimeticsplant homeodomainsprotein‐protein interactions

Identifiers

PMID41243558
PMCPMC12731528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.