Evidence map›Paper›PMID 41243508›Full record

ArticlePathologica2025

A tough NUT carcinoma to crack.

Alessandra Celi, Rossella Bruno, Paola Vignali, Iacopo Petrini, Angelo Valetto, Veronica Bertini, Olivia Fanucchi, Antonio Chella, Greta Alì

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessandra CeliDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Rossella BrunoUnit of Pathological Anatomy, University Hospital of Pisa, Pisa, Italy.
Paola VignaliDepartment of Translational Research and New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.
Iacopo PetriniDepartment of Translational Research and New Surgical and Medical Technologies, University of Pisa, Pisa, Italy.
Angelo ValettoSection of Cytogenetics, Oncology Department, AOUP, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
Veronica BertiniSection of Cytogenetics, Oncology Department, AOUP, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
Olivia FanucchiThoracic Endoscopy Unit, Thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy.
Antonio ChellaSection of Oncopneumology, University Hospital of Pisa.
Greta AlìDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the case of a NUT carcinoma of the thorax in a 27-year-old male, non-smoker, presenting a voluminous neoformation in the hilum and the left side of the mediastinum infiltrating heart and great vessels. The biopsy revealed a poorly differentiated cancer with focal crush artifact consisting of undifferentiated small to medium-size cells, with minimal indistinct to clear cytoplasm, round or oval nuclei, nuclear molding and brisk mitotic activity. Suggestive morphological features often associated with NUT carcinoma, for example abrupt foci of keratinization, were not seen. Moreover, immunohistochemical (IHC) analysis showed negativity for epithelial markers, such as Cytokeratin AE1/AE3, CK7, CK-CAM5.2, CK5/6, p40 and TTF1; therefore, further immunohistochemical markers were evaluated, and the conclusive diagnosis was based on a diffuse speckled nuclear positivity for NUT1 (clone C52B1). Considering the unusual morphological and IHC findings, a comprehensive genome profiling, by FoundationOne®CDx Next Generation Sequencing (NGS), was performed on DNA from the transbronchial needle aspiration formalin-fixed and paraffin-embedded cell block. Neither

Indexed as

Biomarkers, TumorCarcinomaNeoplasm ProteinsNuclear ProteinsOncogene ProteinsAdultDNA Copy Number VariationsHumansImmunohistochemistryMaleBiomarkers, TumorNeoplasm ProteinsNuclear ProteinsNUTM1 protein, humanOncogene Proteinsfusion genemolecular analysisNUT carcinoma

Identifiers

PMID41243508
PMCPMC12620952

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.