Evidence map›Paper›PMID 41243507›Full record

ArticlePathologica2025

Lung and nodal hairy cell leukemia with concurrent infectious granulomatosis: a mimic of metastatic lung epithelial neoplasia.

Massimiliano Mancini, Giulio Maurizi, Evelina Rogges, Stefania Scarpino, Stefano Fratoni, Davide Vacca, Katia Paciaroni, Andrea Vecchione, Arianna Di Napoli

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In one paragraph

Article in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Massimiliano ManciniMorphologic and Molecular Pathology Unit, Sant'Andrea University Hospital, Rome, Italy.
Giulio MauriziDepartment of Thoracic Surgery, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Evelina RoggesDepartment of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, PhD School in Translational Medicine and Oncology, Sapienza University of Rome, Rome, Italy.
Stefania ScarpinoMorphologic and Molecular Pathology Unit, Sant'Andrea University Hospital, Rome, Italy.
Stefano FratoniDepartment of Anatomic Pathology, Sant'Eugenio Hospital of Rome, Rome, Italy.
Davide VaccaTumor Immunology Unit, Department of Sciences for Health Promotion and Mother-Child Care "G. D'Alessandro", University of Palermo, Palermo, Italy.
Katia PaciaroniUOSD Ematologia, ASL Roma 1, Roma, Italy.
Andrea VecchioneDepartment of Clinical and Molecular Medicine, Morphologic and Molecular Pathology Unit, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
Arianna Di NapoliDepartment of Clinical and Molecular Medicine, Morphologic and Molecular Pathology Unit, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hairy cell leukemia (HCL) is a rare, indolent B-cell neoplasm, typically involving bone marrow, spleen, and peripheral blood, with extranodal sites rarely affected. Herein, we present the unique case of a 52-year-old man with lung and lymph node involvement by HCL concurrently with atypical mycobacteriosis. Initial imaging showed mediastinal lymphadenopathy and a pulmonary nodule, which raised suspicion for lung neoplasia. A minimally invasive biopsy of the mediastinal nodes and hilar lesion revealed a lymphoid proliferation mixed with necrotizing granulomatous inflammation, with an immunophenotype consistent with HCL and BRAF V600E mutation, confirmed by digital PCR. Notably, molecular analyses detected atypical mycobacteria in lymph nodes. This unusual co-occurrence of HCL with atypical mycobacterial infection in the lung and lymph nodes poses a complex diagnostic and therapeutic challenge, highlighting the importance of recognizing such presentations to optimize patient management.

Indexed as

Leukemia, Hairy CellLung NeoplasmsMycobacterium Infections, NontuberculousDiagnosis, DifferentialHumansLungLymph NodesMaleMiddle AgedProto-Oncogene Proteins B-rafBRAF protein, humanProto-Oncogene Proteins B-rafatypical mycobacterial infectionBRAF V600E mutationhairy cell leukemialung involvementlymphocytic interstitial pneumonia

Identifiers

PMID41243507
PMCPMC12620953

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.