Evidence map›Paper›PMID 41243435›Full record

ReviewGM crops & food2025

Rethinking gene-edited crop regulation: advancing a Principle-based framework for modern biotechnology governance.

Saarani Vengadesen, Mohammad Firdaus Bin Abdul Aziz, MichaelG K Jones

Abstract readReview
In one paragraph

Review in GM crops & food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Genome editing between wonder and rejection.Frontiers in bioengineering and biotechnology · 2026
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Saarani VengadesenFaculty of Law, Universiti Malaya, Kuala Lumpur, Malaysia.
Mohammad Firdaus Bin Abdul AzizFaculty of Law, Universiti Malaya, Kuala Lumpur, Malaysia.
MichaelG K JonesFood Futures Institute, Murdoch University, Perth, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene editing (GEd) technologies are rapidly transforming agricultural biotechnology; however, their regulatory treatment remains ambiguous under international instruments such as the Cartagena Protocol on Biosafety (CPB), which was originally developed for genetically modified organisms (GMOs). This regulatory uncertainty creates challenges for product developers and regulators. This study critically examines the role of the Precautionary Principle (PP) in governing emerging genetic technologies. While the PP underpins the CPB, its interpretation, particularly in the European Union, has been criticized for creating legal barriers that have delayed the adoption of beneficial technologies. In contrast, a Principle-Based Approach (PBA) provides a more adaptive governance framework, grounded in high-level principles that enable flexibility with evolving scientific evidence. Through a review of global regulatory trends, this study identifies jurisdictional challenges and contrasts the theoretical and practical implications of the PP and PBA. It concludes with policy recommendations advocating a hybrid model integrating precaution and principle-based flexibility.

Indexed as

BiotechnologyCrops, AgriculturalGene EditingPlants, Genetically ModifiedAgricultureEuropean UnionCartagena Protocol on BiosafetyGene EditingGenetically Modified OrganismsLiving Modified OrganismsPrecautionary PrinciplePrinciple-based ApproachProcess-basedProduct-based

Identifiers

PMID41243435
PMCPMC12629328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.