ReviewPhysiological reports2025
Modulation of lactose synthesis and orexinergic-glucose pathway by sex steroid hormones.
Review in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Protein sorting and proteostasis mechanisms in CFTR-related exocrine pancreas dysfunction: A systematic narrative review.Channels (Austin, Tex.) · 2026Pooled it
- Utero-placental calcium and magnesium ion channels: A systematic review of obstetric implications of their alterations.Channels (Austin, Tex.) · 2026Pooled it
- Melatonin as a protector against endocrine disruption across tissues: A systematic review.Physiological reports · 2026Pooled it
- Physiological significance of autocrine orexinergic signaling in extra-hypothalamic tissues.Physiological reports · 2026Pooled it
- Genetic aetiology of global developmental delay and intellectual disability in Africa: a scoping review.Frontiers in genetics · 2026Pooled it
- Orexinergic pathway as a potential therapeutic candidate for the modulation of glucose homeostasis.Frontiers in physiology · 2025Pooled it
- Pooled it
- Gastric Proton Pumpopathy Associated with Protein Sorting Machinery: A Narrative Review.Clinical and experimental gastroenterology · 2026Review
- Modulation of lactose synthesis and orexinergic-glucose pathway by sex steroid hormones.Physiological reports · 2025Review
- Repeated Levonorgestrel Administration Impairs Cognitive Function via Glutamatergic Transmission and CaMKII-PKA-BDNF Signaling in the Hippocampus of Female Wistar Rats.Journal of experimental pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex steroid hormones play a regulatory role in various metabolic processes, including glucose homeostasis via the orexinergic system and lactose synthesis. This review consolidates experimental findings on the mechanisms by which these hormones regulate these two pathways. A systematic search of PubMed, Scopus, and Web of Science identified 15 controlled studies involving animals and humans that investigated the effects of sex steroid hormones on both pathways. Estradiol enhanced orexin neuron excitability and increased orexin-1 receptor expression in a cyclical, phase-dependent manner within the orexinergic-glucose axis, promoting glucose utilization during estrogen-dominant phases. Progesterone reduced this activity, which is consistent with the conservation of energy during the luteal phase. Testosterone diminished orexin-A neuronal activation during glucose deficit, suggesting a suppressive effect on orexin-driven glucose mobilization. Also, estradiol promoted lactogenesis after progesterone withdrawal, whereas progesterone sustained prepartum inhibition of α-lactalbumin and casein gene transcription. In conclusion, the influence of sex steroid hormones on orexinergic-glucose regulation is hormone-specific and phase-dependent, with estradiol acting as a stimulant, progesterone as an inhibitor, and testosterone having a largely suppressive effect. The postpartum decrease in progesterone level triggers estradiol to support milk production. Studies are needed to investigate the role of sex steroid hormones on lactase expression, activity, and lactose tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.