Trial reportJournal of cosmetic dermatology2025
Clinical and Biometric Assessment of a Hyaluronic Acid-Based Skin Booster for Face, Neck and Décolleté Rejuvenation: A Prospective Study.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Clinical and Biometric Assessment of a Hyaluronic Acid-Based Skin Booster for Face, Neck and Décolleté Rejuvenation: A Prospective Study.Journal of cosmetic dermatology · 2025Trial
- The STIIM UP Protocol: Exploratory Evaluation of the Potential of Combined Calcium Hydroxyapatite, Hyaluronic Acid, and Botulinum Toxin A in Neck Rejuvenation.Journal of clinical medicine · 2026Article
- Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study.Plastic and reconstructive surgery. Global open · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyaluronic acid based skinboosters present a low rheological profile that allows for even distribution throughout the dermis and focuses on improving skin's overall quality. Scientific efforts are ongoing with the aim of developing optimal skinboosters that meet specific clinical requirements and satisfactory overall results.
objectiveAssess clinically the efficacy and safety of a newly developed skinbooster known as BtHLINE for face, neck and décolleté rejuvenation. MATERIALS AND
methodsIn this prospective and single-centre clinical trial, 81 volunteers with signs of cutaneous aging received three intradermal injections of BtHLINE every 3 weeks and were followed up for 15 days, 3 months and 6 months. Efficacy evaluation included the Multifactorial Aesthetic Scale (MAS), the Global Aesthetic Improvement Scale (GAIS) and the Likert's patient satisfaction questionnaire. Biometric parameters were also assessed over the facial area using specific aesthetic instrumentation such as Visioscan, Cutometer, Moisturemap and Visioface tools. Adverse events related to the treatment were registered throughout the study.
resultsMAS score reached a statistically significant improvement at each time point for every treated area. Accordingly, GAIS and patient satisfaction surveys showed a clinically noticeable percentage of responders at the end of the follow-up. The biometric analysis revealed that BtHLINE promoted a rapid and significant improvement that was maintained during the follow-up period in terms of cutaneous uniformity, viscoelasticity, flexibility, firmness, water content, hydration, wrinkle depth, surface irregularities, scaling and smoothness. Adverse events were slight and considered as usual among skinboosters and were resolved within a few days.
conclusionThis study demonstrates that BtHLINE is safe and effective for the promotion of skin rejuvenation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.