Evidence map›Paper›PMID 41243321›Full record

ArticleFoot & ankle international2026

Preoperative Cannabis Use and Ankle ORIF Outcomes: Higher Risks of Infection, Nonunion, and Reoperation.

Sri Tummala, Brandon A Wood, Mehul M Mittal, Senthil N Sambandam, Dane K Wukich

Abstract read
In one paragraph

Article in Foot & ankle international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Effect of Comorbidities on Short-Term Postoperative Complications Following total Shoulder Arthroplasty: A TriNetX Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sri TummalaDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0004-8090-4575
Brandon A WoodUniversity of Texas Southwestern Medical School, Dallas, TX, USA.ORCID 0009-0002-7336-9944
Mehul M MittalUniversity of Texas Southwestern Medical School, Dallas, TX, USA.ORCID 0000-0001-8837-0396
Senthil N SambandamDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-7074-9197
Dane K WukichDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-3637-6208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith the widespread legalization and rising prevalence of cannabis use, understanding its impact on perioperative outcomes has become clinically critical. Although recent orthopaedic research has examined cannabis-related risks following various procedures, its implications following surgical fixation of ankle fractures remain unexplored. Given the increasing incidence and complexity of ankle fractures, clarifying these risks is essential for effective perioperative management and patient counseling.

methodsA retrospective cohort analysis was conducted using a nationally representative research database. Patients undergoing open reduction and internal fixation (ORIF) for rotational ankle fractures were identified using standardized

resultsAfter PSM, 3126 matched pairs were included in the analysis. At 90 days postoperatively, cannabis use was significantly associated with increased risks of postoperative infection (RR = 1.696, 95% CI 1.230-2.337,

conclusionPreoperative cannabis use is associated with significantly increased complications following ankle ORIF, notably systemic and hardware infections, nonunion, and reoperation. These findings support recognizing cannabis use as a potentially modifiable perioperative risk factor, akin to tobacco use, underscoring the importance of targeted counseling and strategies aimed at optimizing surgical and patient outcomes.

Indexed as

Ankle FracturesFracture Fixation, InternalFractures, UnunitedMarijuana UseOpen Fracture ReductionSurgical Wound InfectionAdultFemaleHumansMaleMiddle AgedPostoperative ComplicationsPropensity ScoreReoperationRetrospective StudiesRisk FactorsAnkle FractureCannabisNonunionOpen Reduction Internal FixationORIFOutcomesReoperationRisk Factors

Identifiers

PMID41243321
PMCPMC12754024

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.