Evidence map›Paper›PMID 41243311›Full record

ArticleGut microbes2025

The triad of maternal gut-breast milk-infant gut microbial transmission in early life as a critical pathway for microbial inheritance.

Yanli Du, Jing Cheng, Ruixia Xie, Yongke Zhang, Zhili Huang, Gang Jin, Xiulan Dong, Dayong Sun, Bingxiang Yang, Zongli Han and 1 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yanli DuSchool of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, China.
Jing ChengDepartment of Obstetrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Ruixia XieSchool of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, China.
Yongke ZhangDepartment of Obstetrics, Peking University Shenzhen Hospital, Shenzhen, China.
Zhili HuangSchool of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, China.
Gang JinSchool of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, China.
Xiulan DongDepartment of Obstetrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Dayong SunDepartment of Gastroenterology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Bingxiang YangSchool of Nursing, Wuhan University, Wuhan, China.
Zongli HanDepartment of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen, China.
Xiangyu WangDepartment of Gastroenterology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although maternal microbial inheritance is recognized, the temporal dynamics of how the maternal gut microbiota shapes the infant gut microbiota via specific routes remain unexplored. We performed longitudinal, multi-site microbiota sampling in 30 mother-infant pairs (including 14 exclusive breastfeeding and 16 mixed breastfeeding) from birth to one month, stratified by lactation stages. To trace the origin of breast milk microbiota, we also analyzed colostrum and gut samples from 8 postpartum mothers separated from their infants. Using 16S RNA sequencing, we analyzed microbial diversity and correlations across lactation stages. The results demonstrated that the gut microbiota of exclusively breastfed newborns on the first day primarily originated from breast milk and exhibited remarkably high diversity. We identified maternal gut-breast milk-infant gut transfer as a key pathway for microbial inheritance, with

Indexed as

BacteriaGastrointestinal MicrobiomeGastrointestinal TractMilk, HumanAdultBreast FeedingColostrumFemaleHumansInfantInfant, NewbornLactationLongitudinal StudiesMothersRNA, Ribosomal, 16SRNA, Ribosomal, 16SBifidobacteriabreastfeeding patternsbreast milk microbiotainfant gut microbiotaMaternal-infant microbial transmission

Identifiers

PMID41243311
PMCPMC12629333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.