Evidence map›Paper›PMID 41243288›Full record

ReviewImmunological reviews2025

Monocyte-Derived Dendritic Cells: An Updated View on an Old Concept.

Elodie Segura

Abstract readReview
In one paragraph

Review in Immunological reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026
    Review
  2. Macrophage heterogeneity in human secondary lymphoid organs.Clinical science (London, England : 1979) · 2026
    Review
  3. Biochemistry and biophysics reports · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Elodie SeguraInstitut Necker Enfants Malades-INEM, CNRS, INSERM, Université Paris Cité, Paris, France.ORCID https://orcid.org/0000-0003-1795-1921

Funding

Institut National de la Santé et de la Recherche Médicale
6 · The paper itself

Abstract

Dendritic cells comprise several populations with distinct ontogeny that share core features including a typical dendritic morphology and the ability to present antigens and stimulate T cells. Dendritic cells originating from monocytes have been reported in steady-state and in different inflammatory contexts, in mouse models and in human clinical samples. However, because of their phenotypical and transcriptional proximity with other dendritic cell subsets and with monocyte-derived macrophages, whether monocyte-derived dendritic cells (mo-DCs) represent a distinct population has been controversial. Here, we summarize the evidence supporting the existence of mo-DCs in vivo and we review work addressing the molecular regulation of mo-DCs differentiation and their role in immune responses. We also discuss the potential for harnessing mo-DCs differentiation for therapy.

Indexed as

Dendritic CellsMonocytesAnimalsAntigen PresentationCell DifferentiationHumansMicedendritic cellshumanmonocytemouse

Identifiers

PMID41243288
PMCPMC12620540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.