ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
RADA16 and SAAP148 Peptide-Modified Collagen Self-Assembled Hydrogels for Accelerated Healing of Infected Wounds.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Fundamentals and Advances in Programmable Peptide Hydrogels for Multifunctional Biomedical Applications: A Review.Gels (Basel, Switzerland) · 2026Review
- Recent advances in multimodal foundation model-enabled peptide screening and optimization for smart biomaterials and functional tissue engineering.Frontiers in bioengineering and biotechnology · 2026Review
- RADA16 and SAAP148 Peptide-Modified Collagen Self-Assembled Hydrogels for Accelerated Healing of Infected Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infected wounds suffer from limited self-healing, persistent bacterial infections, prolonged inflammation, and oxidative wound microenvironment. While anti-bacterial peptides such as SAAP148 demonstrate remarkable efficacy against drug-resistant pathogens, their clinical application is hindered by rapid inactivation and uncontrolled burst release. To address these limitations, collagen type I (Col I) is integrated with self-assembling peptide RADA16 to develop a novel self-assembled nano-micro structured hydrogel (Col I-RADA16, CR) without chemical cross-linkers. This unique design leverages the micron-scale porous structure of Col I and the nanofibrous architecture of RADA16, resulting in a hydrogel with excellent mechanical properties, sustained SAAP148 release, and enhanced bioactivity. CR not only promotes fibroblast adhesion, migration, and proliferation, but when loaded with SAAP148 (Col I-RADA16-SAAP148, CRS), effectively inhibits bacterial infection, enhances macrophage polarization and accelerates wound healing in vivo. Importantly, histological and immunohistochemical analyses revealed that the CRS hydrogel significantly enhances regeneration of skin appendages (e.g., hair follicles and glands) by action of CK5 and CK14 in the ERBB/MAPK, mTOR/PI3K-Akt, JNK/p38 MAPK signaling axes, significantly surpassing the performance of traditional collagen or gelatin sponges. This innovative dual-scale design and cross-linker-free fabrication strategy offers a versatile and clinically translatable platform for infected wound healing, addressing critical limitations in current wound care technologies.
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Registered trials
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