ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2026
Temporal Bone 3D Reconstruction and Analysis of Endolymph Volume in Meniere Disease.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
hypothesisEndolymph volumes within the cochlea and vestibule differ between Meniere's disease (MD) and similar-age controls.
backgroundMagnetic resonance imaging (MRI) has potential to diagnose endolymphatic hydrops (EH). In this study, we utilize archival human temporal bones (HTB) to establish objective reference values for endolymph volumes within the cochlea and vestibule in patients with MD and in age-similar controls, for correlation with future MRI studies.
methodsNineteen HTBs were selected for 3-dimensional reconstruction and volume analysis, including 12 HTBs with MD and 7 age-similar control HTBs. HTBs were segmented and volumes of interest were measured allowing for calculation of the vestibular and cochlear endolymphatic ratios (vELR and cELR), representative of the degree of EH within the vestibule and cochlea.
resultsEndolymph volumes within the vestibule and cochlea were significantly higher in MD HTBs. There was no difference in volumes of the bony vestibule and cochlea. The vELR and cELR were significantly larger in MD. Control HTB measurements were utilized to establish the upper bound of normal for the vELR and cELR, which were determined to be 33.2% and 8.84%, respectively.
conclusionsEndolymph volumes and the corresponding vELR and cELR values were significantly higher in MD, indicative of EH. Through the ELR, this study provides objective anatomic reference values directly comparable to MRI studies of EH. A threshold for the vELR and cELR is proposed, above which a diagnosis of EH may be warranted.
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