Evidence map›Paper›PMID 41243054›Full record

ArticleBrain tumor pathology2026

Histopathological evaluation of dopamine receptor D2 expression in symptomatic gonadotroph pituitary neuroendocrine tumors: a case series including a rare metastatic case responsive to a dopamine agonist.

Ken Uekawa, Naoki Shinojima, Takahiro Yamamoto, Shigeo Anai, Kozo Tashima, Motoyuki Igata, Takeshi Matsumura, Rumi Sasaki, Takashi Ohba, Hironori Tashiro and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain tumor pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ken UekawaDepartment of Neurosurgery, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. kenuekawa@gmail.com.ORCID http://orcid.org/0000-0001-8952-7009
Naoki ShinojimaDepartment of Neurosurgery, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Takahiro YamamotoDepartment of Neurosurgery, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Shigeo AnaiDepartment of Neurosurgery, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Kozo TashimaDepartment of Neurosurgery, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Motoyuki IgataDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Kumamoto, 860-8556, Japan.
Takeshi MatsumuraDepartment of Medical Technology, Faculty of Health Sciences, Kumamoto Health Science University, Kumamoto, 861-5598, Japan.
Rumi SasakiDepartment of Obstetrics and Gynecology, Kumamoto University Hospital, Kumamoto, 860-8556, Japan.
Takashi OhbaDepartment of Obstetrics and Gynecology, Kumamoto University Hospital, Kumamoto, 860-8556, Japan.
Hironori TashiroDepartment of Reproductive Health, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0976, Japan.
Kazuhito TanakaDepartment of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, 860- 8556, Japan.
Kentaro TanakaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Hiroyo MabeDepartment of Pediatrics, Kumamoto University Hospital, Kumamoto, 860-8556, Japan.
Shigetoshi YanoDepartment of Neurosurgery, Minamifukuoka Neurosurgical Hospital, Fukuoka, 811-1313, Japan.
Toshinori HiraiDepartment of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Yoshiki MikamiDepartment of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, 860- 8556, Japan.
Akitake MukasaDepartment of Neurosurgery, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functioning gonadotroph pituitary neuroendocrine tumors (Gn-PitNETs) cause ovarian hyperstimulation. We report Gn-PitNETs, including a distant metastasis case responsive to a dopamine agonist (DA), cabergoline. A 10-year-old girl presented with ovarian enlargement and elevated FSH levels (33.7 mIU/mL). A pituitary tumor was resected and confirmed as a Gn-PitNET. Radiotherapy for residual tumor improved ovarian enlargement. At age 20, ovarian enlargement recurred and cabergoline relieved symptoms and decreased FSH levels. At age 35, ovarian enlargement recurred after discontinuing cabergoline but improved with its reinstatement. Liver biopsy confirmed metastatic Gn-PitNET and DRD2 positivity. A 26-year-old woman presented with ovarian enlargement and elevated FSH levels (31.6 mIU/mL). A pituitary tumor was resected and confirmed as a Gn-PitNET with negative DRD2. FSH levels normalized, and ovarian size improved. A 48-year-old man presented with bitemporal hemianopia. FSH levels were elevated (251.4 mIU/mL) without testicular enlargement. The pituitary tumor was resected, improving hemianopia and normalizing FSH levels. Histopathology confirmed a Gn-PitNET with strong FSH staining and DRD2 positivity. In a rare case of metastatic Gn-PitNET, cabergoline was associated with tumor stability and hormone control. Further studies may clarify whether DRD2 expression can help predict DA responsiveness in refractory tumors.(200/200 words).

Indexed as

Dopamine AgonistsNeuroendocrine TumorsPituitary NeoplasmsReceptors, Dopamine D2AdultCabergolineChildFemaleFollicle Stimulating HormoneGonadotrophsHumansMaleMiddle AgedYoung AdultCabergolineDopamine AgonistsDRD2 protein, humanFollicle Stimulating HormoneReceptors, Dopamine D2Dopamine agonistsDopamine receptor D2 (DRD2)Functioning gonadotroph pituitary neuroendocrine tumors (Gn-PitNETs)Metastatic pituitary neuroendocrine tumors (PitNETs)Ovarian hyperstimulation

Identifiers

PMID41243054
PMCPMC13375684

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.