Evidence map›Paper›PMID 41242630›Full record

ArticleJournal of the American Academy of Dermatology2026

Population differences in Merkel cell carcinoma by virus status and anatomic site: A multi-cohort analysis including institutional, SEER, and NCDB data.

Mackenzie R Martin, Serena M Vilasi, Yoshine Saito, Noreen Mohsin, Jordan E Jarvis, Patrick Hallaert, Danielle J Reed, Lingling Miao, Jacob T Tribble, Elizabeth K Cahoon and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Academy of Dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mackenzie R MartinDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland; NYU Grossman School of Medicine, New York, New York.
Serena M VilasiSchool of Medicine, University of Virginia, Charlottesville, Virginia.
Yoshine SaitoDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Noreen MohsinDepartment of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.
Jordan E JarvisDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Patrick HallaertDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Danielle J ReedDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Lingling MiaoDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.
Jacob T TribbleDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.
Elizabeth K CahoonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.
Ruth M PfeifferDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.
Krista LachanceDivision of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.
Rima KulikauskasDivision of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.
Paul NghiemDivision of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.
Isaac BrownellDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: isaac.brownell@nih.gov.

Funding

Molecular pathogenesis and therapy innovation for Merkel cell carcinomaZIAAR041222 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI BROWNELL, ISAAC · 2022 to 2025
$4.0M
Intramural NIH HHS ZIA AR041222
6 · The paper itself

Abstract

backgroundThe impact of race/ethnicity on Merkel cell carcinoma (MCC) outcomes remains inconclusive.

objectiveTo examine associations between MCC primary site, virus status, environmental ultraviolet radiation (UVR), and race/ethnicity.

methodsPatients diagnosed with MCC at the University of Washington (UW), in Surveillance, Epidemiology, and End Results (SEER-17), in National Cancer Database (NCDB), and global incidence and virus status data were included in this retrospective multi-cohort study. We estimated the prognostic effect of virus status using a Cox proportional hazards model, conducted a pooled analysis of tumor site and virus status, and investigated racial/ethnic differences in site using SEER and NCDB. We also estimated global MCC viral subtype incidences and assessed their association with geographic UV indices.

resultsVirus-positive MCC (VP-MCC) showed improved survival compared to virus-negative MCC (VN-MCC) (P < .001) and was more likely to develop on UV-protected skin (P < .001). Black and Hispanic patient tumors were more likely to present on UV-protected sites (P < .001). Globally, UVR had a bigger effect on VN-MCC incidence than VP-MCC. LIMITATIONS: Nonstandardized virus assays, unknown patient migration histories, incomplete global data, and registry selection bias.

conclusionBlack and Hispanic patients more often develop MCC on UV-protected sites, which are more likely VP-MCC and associated with improved outcomes.

Indexed as

Carcinoma, Merkel CellSkin NeoplasmsAgedAged, 80 and overDatabases, FactualFemaleHumansIncidenceMaleMiddle AgedPrognosisProportional Hazards ModelsRetrospective StudiesSEER ProgramUltraviolet RaysUnited Statesepidemiologyhealthcare disparitiesMerkel cell carcinomaMerkel cell polyomavirusoncologyultraviolet radiation

Identifiers

PMID41242630
PMCPMC13595424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.