Evidence map›Paper›PMID 41242604›Full record

ArticleJournal of invertebrate pathology2026

Substitutions in the cardiac glycoside binding site of the Na

Perla Achi, Cullen McCarthy, Lanie Bavier, Robert Pena, W Nate Collison, Victoria Iglesias, Preston Christensen, Ahmed Aljidui, Anil Baniya, Connor Goldy and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of invertebrate pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Perla AchiDepartment of Nematology, University of California, Riverside, CA, USA.
Cullen McCarthyDepartment of Nematology, University of California, Riverside, CA, USA.
Lanie BavierDepartment of Nematology, University of California, Riverside, CA, USA.
Robert PenaDepartment of Nematology, University of California, Riverside, CA, USA.
W Nate CollisonDepartment of Nematology, University of California, Riverside, CA, USA.
Victoria IglesiasDepartment of Nematology, University of California, Riverside, CA, USA.
Preston ChristensenDepartment of Nematology, University of California, Riverside, CA, USA.
Ahmed AljiduiDepartment of Nematology, University of California, Riverside, CA, USA.
Anil BaniyaDepartment of Nematology, University of California, Riverside, CA, USA.
Connor GoldyDepartment of Nematology, University of California, Riverside, CA, USA.
Rose C AdrianzaDepartment of Nematology, University of California, Riverside, CA, USA.
Suraj ReddyDepartment of Nematology, University of California, Riverside, CA, USA.
Simon C GroenDepartment of Nematology, University of California, Riverside, CA, USA; Center for Infectious Disease and Vector Research, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA. Electronic address: simon.groen@ucr.edu.
Adler R DillmanDepartment of Nematology, University of California, Riverside, CA, USA; Center for Infectious Disease and Vector Research, Institute for Integrative Genome Biology, University of California, Riverside, CA, USA. Electronic address: adlerd@ucr.edu.

Funding

Molecular mayhem: Immune modulation and eicosanoid signaling during infectionR35GM137934 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Adler Ray Dillman · 2020 to 2026
$2.3M
NIGMS NIH HHS R35 GM137934
6 · The paper itself

Abstract

Soil salinity varies widely across geographies both due to natural factors and human activities, including agriculture, road salt application, sea level rise, and desertification. Increases in soil salinity may affect organisms widely and particularly impact soil food webs. As parasites, entomopathogenic nematodes (EPNs) occupy crucial links in soil food webs and are important for agriculture as biological control agents of insect pests. Previous research found that the EPN Steinernema carpocapsae may exhibit higher salt tolerance than several of its congeners. We recently identified that S. carpocapsae uniquely evolved two amino acid substitutions in the first extracellular loop of the sodium pump (Na

Indexed as

Helminth ProteinsRhabditidaSalt ToleranceSodium-Potassium-Exchanging ATPaseAmino Acid SubstitutionAnimalsBinding SitesHelminth ProteinsSodium-Potassium-Exchanging ATPaseAmino acid substitutionEntomopathogenic nematodesEvolutionIntramolecular epistasisNa(+)/K(+)-ATPaseSalinitySteinernema

Identifiers

PMID41242604
PMCPMC13148293

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.