Evidence map›Paper›PMID 41242527›Full record

ArticleThe journal of pain2026

Distress is positively associated with induced secondary hyperalgesia in people with suppressed HIV.

Luyanduthando Mqadi, Gillian J Bedwell, Ncumisa Msolo, Gwendoline Arendse, Maia Lesosky, Peter R Kamerman, Mark R Hutchinson, Andrew Schrepf, Robert R Edwards, John A Joska and 2 more

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In one paragraph

Article in The journal of pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Luyanduthando MqadiAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Gillian J BedwellAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Ncumisa MsoloAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Gwendoline ArendseAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Maia LesoskyNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Peter R KamermanBrain Function Research Group, Department of Physiology, School of Biomedical Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mark R HutchinsonSchool of Biomedicine, University of Adelaide, South Australia, Australia; Institute for Photonics and Advanced Sensing, University of Adelaide, South Australia, Australia.
Andrew SchrepfChronic Pain and Fatigue Research Center, Department of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Robert R EdwardsDepartment of Anesthesiology, Perioperative, and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
John A JoskaHIV Mental Health Research Unit, Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Romy ParkerAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Victoria J MaddenAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa; HIV Mental Health Research Unit, Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Electronic address: torymadden@gmail.com.

Funding

Psychosocial distress, inflammatory reactivity and central sensitization in the pathway to HIV-related pain: characterizing the associations and developing a pragmatic, coping-focused intervention.K43TW011442 · FIC · UNIVERSITY OF CAPE TOWN · PI MADDEN, VICTORIA JOY · 2019 to 2023
$674k
Mentorship in Precision Pain Medicine via EPPIC-NETK24NS126570 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R · 2021 to 2021
$319k
FIC NIH HHS K43 TW011442NINDS NIH HHS K24 NS126570
6 · The paper itself

Abstract

Pain and symptoms of depression and anxiety (here, 'psychological distress') are frequently reported by people with HIV. Although pain is widely acknowledged to contribute to distress, distress may also contribute to pain and its persistence. Facilitation of nociceptive signalling is one pathway by which distress could exacerbate pain. The current study investigated the relationships between symptoms of depression and anxiety, secondary hyperalgesia (SH), and persistent pain in people with HIV, reporting pain (n=19) or no pain (n=26). We hypothesised that self-reported distress would be positively associated with the surface area (primary measure) and magnitude (secondary measure) of induced SH, and that participants reporting persistent pain would display greater induced SH than those reporting no pain. We found that distress was positively associated with the surface area (p=0.02) and the magnitude (p=0.01) of induced SH. However, participants with persistent pain showed no difference in the surface area of SH compared to pain-free participants (p=0.87), and those with pain displayed a marginally lower magnitude of SH (p=0.05). These findings position SH as a potentially useful mechanistic outcome for interventions that aim to address pain by reducing symptoms of depression and anxiety. PERSPECTIVE: Symptoms of depression and anxiety were positively associated with induced secondary hyperalgesia in people with suppressed HIV.

Indexed as

AnxietyDepressionHIV InfectionsHyperalgesiaPsychological DistressAdultFemaleHumansMaleMiddle AgedPain MeasurementDistressHIVPain-freePersistent painSecondary hyperalgesia

Identifiers

PMID41242527
PMCPMC13373244

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.