ReviewCurrent opinion in hematology2026
Limitations of rituximab in treating primary immune thrombocytopenia and the therapeutic potentials of alternatives.
Review in Current opinion in hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewPrimary immune thrombocytopenia (ITP), an immune-mediated hemorrhagic disease, features an intricate pathogenesis that involves megakaryocyte malfunction and hyperresponsiveness of the innate and adaptive immune systems. As a second-line drug for ITP, rituximab acts quickly and can produce an initial response rate of up to 60%. However, this response only lasts for a short term, meanwhile challenged by resistance, relapse and side effects. Additionally, no reliable clinical parameters have been proposed for forecasting the therapeutic response of patients. Furthermore, the application of rituximab is restricted in specific populations, including pregnant patients, children with positive antithyroid antibodies, and patients contaminated with HBV. RECENT
findingsSplenectomy and new drugs that target the thrombopoietin receptor, FcγR, FcRn, B-cells or plasma cells, T-cells, and complement pathways may overcome these shortcomings. SUMMARY: This article summarizes the barriers limiting the use of rituximab, and discusses the effectiveness and safety of current and fledgling treatment options.
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