Evidence map›Paper›PMID 41241946›Full record

ArticleCell reports2025

Non-uniform contextual interactions in the visual cortex place fundamental limits on spatial vision.

Mitchell P Morton, Sachira Denagamage, Nyomi V Hudson, Anirvan S Nandy

Abstract read
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mitchell P MortonDepartment of Neuroscience, Yale University, New Haven, CT 06510, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA.
Sachira DenagamageDepartment of Neuroscience, Yale University, New Haven, CT 06510, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA.
Nyomi V HudsonDepartment of Neuroscience, Yale University, New Haven, CT 06510, USA.
Anirvan S NandyDepartment of Neuroscience, Yale University, New Haven, CT 06510, USA; Department of Psychology, Yale University, New Haven, CT 06511, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA; Wu Tsai Institute, Yale University, New Haven, CT 06511, USA; Kavli Institute for Neuroscience, Yale University, New Haven, CT 06511, USA. Electronic address: anirvan.nandy@yale.edu.

Funding

Interdepartmental Neuroscience Program (INP)T32NS041228 · NINDS · YALE UNIVERSITY · PI Charles A Greer, Marina R Picciotto · 2001 to 2026
$12.0M
Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI In-Jung Kim · 2016 to 2026
$7.1M
NEUROBIOLOGY OF CORTICAL SYSTEMST32NS007224 · NINDS · YALE UNIVERSITY · PI CARDIN, JESSICA A · 1985 to 2025
$4.6M
Neural Mechanisms of Visual CrowdingR01EY032555 · NEI · YALE UNIVERSITY · PI Anirvan S. Nandy · 2022 to 2026
$2.2M
NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY032555NINDS NIH HHS T32 NS007224NINDS NIH HHS T32 NS041228
6 · The paper itself

Abstract

A common assumption is that contextual integration in the primary visual cortex (V1) is spatially uniform. However, perceptual phenomena such as visual crowding reveal non-uniform interactions, with flankers at specific geometries exerting stronger effects. To resolve this discrepancy, we investigated how flanker geometry impacted the representation of a target stimulus in the laminar microcircuits of V1. Our study indicates that flanker location differentially impairs stimulus representation in excitatory neurons in the superficial and input layers of V1 through tuned suppression and untuned facilitation of orientation responses. Mechanistically, this effect can be explained by asymmetrical spatial kernels in a normalization model of cortical activity. Strikingly, these non-uniform modulations of neural representation mirror perceptual anisotropies. These results demonstrate that the non-uniform spatial integration of information in the earliest stages of cortical processing places a fundamental limit on spatial vision.

Indexed as

Primary Visual CortexSpace PerceptionVision, OcularVisual CortexAnimalsMaleNeuronsPhotic StimulationVisual Perceptioncontext modulationCP: neurosciencelaminar circuitperceptual asymmetrysurround modulationV1visionvisual cortexvisual crowding

Identifiers

PMID41241946
PMCPMC12740235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.