Evidence map›Paper›PMID 41241911›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Gain-of-Functional Genomic Screening for Microproteins Essential for Tumorigenesis.

Anni Ge, Yuan Gao, Xiaolong Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anni GeDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Yuan GaoDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
Xiaolong YangDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada. yangx@queensu.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mounting studies suggest that the protein-coding potential of the human genome is underestimated, and previously unannotated open reading frames (ORFs) have been revealed with technological advances. Although the coding potential of many non-canonical ORFs (ncORFs) is now recognized, their functional prevalence remains to be characterized, partly due to the technical difficulty and labour intensity in screening numerous ncORFs at once. Here, we describe a gain-of-function genomic screen to identify functional ncORF-encoded proteins responsible for breast cancer tumorigenesis. This method is thought to improve the efficiency of characterizing previously neglected ncORFs and reveal potential targets for cancer treatment.

Indexed as

Breast NeoplasmsCarcinogenesisGenomicsCell Line, TumorFemaleHumansMicropeptidesOpen Reading FramesMicropeptidesCancer biologyFunctional genomic screenGain-of-function screenMicropeptidesMicroproteinsncORFsmORFTumorigenesis

Identifiers

PMID41241911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.