Evidence map›Paper›PMID 41241907›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Functional Testing of Microproteins in a Vertebrate Model of Development.

Anthony J Treichel, Ariel A Bazzini, Valerie A Tornini

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anthony J TreichelStowers Institute for Medical Research, Kansas City, MO, USA.
Ariel A BazziniStowers Institute for Medical Research, Kansas City, MO, USA.
Valerie A TorniniDepartment of Integrative Biology and Physiology; Institute for Society and Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA, USA. vtornini@ucla.edu.

Funding

Small translated ORFs in the 3'UTR enhance translation in vertebratesR01GM136849 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI BAZZINI, ARIEL · 2021 to 2025
$2.0M
Functional analysis of histone modifier Autism Spectrum Disorders risk genes in vertebrate developmentR00HD105001 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie Angela Tornini · 2024 to 2026
$737k
CRISPR-Cas13d: Transgenic zebrafish lines toknockdown mRNAR21OD034161 · OD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI BAZZINI, ARIEL · 2023 to 2024
$454k
NICHD NIH HHS R00 HD105001NIGMS NIH HHS R01 GM136849NIH HHS R21 OD034161
6 · The paper itself

Abstract

While thousands of putative microproteins have been identified through ribosome profiling, reporter assays, and mass spectrometry-based methods, their functional testing has remained challenging. Advances in genome sequencing and CRISPR/Cas technologies enable the prioritization and testing of candidate microprotein functions for roles in development, for example, in the maternal-to-zygotic transition or in neurodevelopment. Here, we describe the functional testing of microproteins in vivo using a vertebrate model of early development, Danio rerio (zebrafish).

Indexed as

ZebrafishZebrafish ProteinsAnimalsCRISPR-Cas SystemsEmbryonic DevelopmentGene Expression Regulation, DevelopmentalMicropeptidesRibosomesMicropeptidesZebrafish ProteinsBehaviorCRISPR/Cas13dCRISPR/Cas9DevelopmentMaternal-zygoticMicroproteinsVertebrate

Identifiers

PMID41241907

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.