ArticleMethods in molecular biology (Clifton, N.J.)2026
Structure and Disorder Predictions of Microproteins: Usage, Applications, and Pitfalls.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Microproteins in Human Physiology and Pathology.Biochemistry · 2026Review
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Abstract
In the past decade, computational predictions of protein structure and disorder have become widely accessible, achieving accuracy that, in some cases, rivals experimental results. These advances have been instrumental in identifying structural homologies, guiding protein design, and enhancing functional annotation. However, most prediction models are trained on "classical proteins," favoring specific sequence lengths and patterns, leading to biases. Microproteins-small proteins with emerging roles in development and disease-function similarly across the tree of life and stand to benefit significantly from structure and disorder predictions. Yet, their short length and molecular interactions present unique challenges, making homology detection more difficult and requiring careful methodological considerations. Here, I outline workflows for predicting, analyzing, and refining microprotein structures and disorders, emphasizing key precautions to ensure reliable insights.
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Registered trials
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