Evidence map›Paper›PMID 41241693›Full record

ArticleArchives of osteoporosis2025

Utility of FRAX® and FRAXplus® in predicting prevalent radiographic vertebral fractures in postmenopausal women from a rural hospital in Southern India-FRACHAMB study (FRActure Christian Hospital AMBilikkai).

Jacob Cherian, Kripa Elizabeth Cherian, Cynthia Susan John, Dharmasivam Vinodhini, Baren Minz, Shiela Cherian, P O Esmy, Vinay Kuruvilla, Palanisamy Manoranjan, Thomas V Paul

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Article in Archives of osteoporosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jacob Cherian *Departments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India.
Kripa Elizabeth Cherian *Department of Endocrinology, Christian Medical College, Vellore, 632004, India.
Cynthia Susan JohnDepartments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India.
Dharmasivam VinodhiniDepartments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India.
Baren MinzDepartments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India.
Shiela CherianDepartments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India.
P O EsmyDepartments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India.
Vinay KuruvillaDepartments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India.
Palanisamy ManoranjanDepartments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India.
Thomas V PaulDepartments of Medical Sciences and Orthopedics, Christian Hospital, Ambilikkai, 624612, India. thomasvpaul@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In alignment with previous studies using the densitometric vertebral fracture assessment tool, the prevalence of radiographic moderate-severe vertebral fractures in rural postmenopausal women was 34%. FRAXplus could bring one additional woman to treatment intervention thresholds who may have otherwise been missed had additional risk factors not been captured. PURPOSE: To study the prevalence of radiographic vertebral fractures and the utility of FRAXplus® and FRAX® in predicting prevalent vertebral fractures in rural southern India.

methodsThis cross-sectional study involved 150 rural postmenopausal women, and they were assessed for radiographic vertebral fractures. FRAX® and FRAXplus® were utilized for computing a 10 year risk of major osteoporotic fractures (MOF) and hip fractures (HF) based on clinical risk factors.

resultsThe mean (SD) age of the patients was 66.1 (6.5) years and BMI (kg/m

conclusionOne-third of rural postmenopausal women had fragility fractures detected on a lateral spine X-ray. Although FRAX® at established Indian cut-offs does help in identifying most women who require anti-osteoporotic treatment, the utilization of FRAX plus® will help in further detecting women who are at borderline risk and may otherwise miss out on treatment if additional risk factors are not captured.

Indexed as

Osteoporosis, PostmenopausalOsteoporotic FracturesSpinal FracturesAgedBone DensityCross-Sectional StudiesFemaleHospitals, RuralHumansIndiaMiddle AgedPostmenopausePrevalenceRisk AssessmentRisk FactorsRural PopulationFRAXplusPostmenopausal womenRuralVertebral fractures

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.