Evidence map›Paper›PMID 41241593›Full record

ArticleAcademic radiology2026

Comparing Mean-anchored Generalized Linear Binning with Established Methods to Quantify Xenon-129 Ventilation Defect Percentage.

Riaz Hussain, Abdullah S Bdaiwi, Joseph W Plummer, Bilal I Masokano, Matthew M Willmering, Laura L Walkup, Zackary I Cleveland

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Academic radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Riaz HussainDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (R.H., A.S.B., J.W.P., B.I.M., M.M.W., L.L.W., Z.I.C.).
Abdullah S BdaiwiDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (R.H., A.S.B., J.W.P., B.I.M., M.M.W., L.L.W., Z.I.C.).
Joseph W PlummerDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (R.H., A.S.B., J.W.P., B.I.M., M.M.W., L.L.W., Z.I.C.); Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH (J.W.P., B.I.M., L.L.W., Z.I.C.).
Bilal I MasokanoDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (R.H., A.S.B., J.W.P., B.I.M., M.M.W., L.L.W., Z.I.C.); Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH (J.W.P., B.I.M., L.L.W., Z.I.C.).
Matthew M WillmeringDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (R.H., A.S.B., J.W.P., B.I.M., M.M.W., L.L.W., Z.I.C.); Department of Pediatrics, University of Cincinnati, Cincinnati, OH (M.M.W., L.L.W., Z.I.C.).
Laura L WalkupDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (R.H., A.S.B., J.W.P., B.I.M., M.M.W., L.L.W., Z.I.C.); Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH (J.W.P., B.I.M., L.L.W., Z.I.C.); Department of Pediatrics, University of Cincinnati, Cincinnati, OH (M.M.W., L.L.W., Z.I.C.); Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (L.L.W., Z.I.C.).
Zackary I ClevelandDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (R.H., A.S.B., J.W.P., B.I.M., M.M.W., L.L.W., Z.I.C.); Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH (J.W.P., B.I.M., L.L.W., Z.I.C.); Department of Pediatrics, University of Cincinnati, Cincinnati, OH (M.M.W., L.L.W., Z.I.C.); Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (L.L.W., Z.I.C.). Electronic address: zackary.cleveland@cchmc.org.

Funding

Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung DiseaseR01HL151588 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I, ZIADY, ASSEM G · 2021 to 2025
$3.9M
Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
Early detection of pulmonary complications of hematopoietic stem-cell transplantation in children using hyperpolarized xenon MRIR01HL166335 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Laura Lee Walkup · 2023 to 2026
$2.7M
NHLBI NIH HHS R01 HL126771NHLBI NIH HHS R01 HL143011NHLBI NIH HHS R01 HL151588NHLBI NIH HHS R01 HL166335
6 · The paper itself

Abstract

RATIONALE AND

objectivesHyperpolarized xenon-129 ( MATERIALS AND

methods

resultsUsing N4-corrected images, all methods-except Hierarchical-showed significant difference in VDP between participants with CF and HCs (P<0.05). For FA-corrected images, similar significance was observed for all methods (P<0.05), except Hierarchical and Adaptive. While Mean

conclusionMean

Indexed as

Cystic FibrosisMagnetic Resonance ImagingXenon IsotopesAdultCase-Control StudiesFemaleHumansImage Interpretation, Computer-AssistedMaleSensitivity and SpecificityYoung AdultXenon-129Xenon IsotopesCystic FibrosisHyperpolarized Xenon MRILung ImagingMean-anchored Generalized Linear BinningVentilation Defect Percentage

Identifiers

PMID41241593
PMCPMC12928158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.