ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026
Reconstitution of thymopoiesis via implantation of cryopreserved cultured thymus tissue into athymic recipients.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Thymic health and implications for chronic kidney disease.Nature reviews. Nephrology · 2026Article
- Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice.Frontiers in immunology · 2026Article
- Mechanism and intervention strategy of thymus atrophy in cancer immunotherapy.American journal of cancer research · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Implantation of cultured allogeneic thymus tissue (CTTI) into athymic human recipients generates functional recipient-derived naïve T cells that are tolerant to the donor. Currently, CTTI is always performed with 12 to 21 days of thymus procurement to avoid culture-related changes that could be detrimental to its reconstitution potential. We demonstrate here that cultured thymus tissue can be cryopreserved and still maintain its viability and reconstitution potential. Implantation of cryopreserved cultured rat thymus tissue (cCTTI) under the renal capsule of congenitally athymic rats results in colonization of the thymus implant with T cell progenitors and population of the periphery with genetically-recipient naïve T cells. Similarly, cCTTI of porcine thymus into the quadriceps muscle of thymectomized T cell-depleted pigs results in full reconstitution of the implanted thymus. Human thymus tissues that are similarly cultured and cryopreserved continue to meet the same implantation quality criteria as freshly cultured thymus tissue. Clinical trials are warranted to test the potential of cCTTI to decouple the current links between time of procurement and implantation. This would extend the benefits of immune reconstitution and tolerance induction to a broader range of patients.
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