Evidence map›Paper›PMID 41241060›Full record

Trial reportJournal of the American College of Radiology : JACR2026

A Multilevel Approach to Improve Participation in Low-Dose CT for Lung Cancer Screening (Empower LCS): A Single-Arm Pilot Feasibility Clinical Trial.

Alireza Shojazadeh, Raymond Kao, Thao Pham, Aarushi Madan, Richard Echeverria, Wen-Pin Chen, Victoria Nguyen, Omar Gutierrez, Sunmin Lee, Michael A Hoyt and 4 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American College of Radiology : JACR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07711691 (Empowering Patients' Lung Cancer Screening Uptake), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07711691 nanot yet recruitingnot on this map

Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+): A Multi-Site Pilot Randomized Controlled Trial

TypeinterventionalSponsorUniversity of California, IrvineRan2026 to 2028Enrolled80ConditionsLung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of CancerArmsEmpower LCS, Call+ Telephone Navigation, Usual Care, Education
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alireza ShojazadehDepartment of Radiological Sciences, University of California, Irvine, California.
Raymond KaoUniversity of California, Los Angeles, California.
Thao PhamDepartment of Radiological Sciences, University of California, Irvine, California.
Aarushi MadanDepartment of Radiological Sciences, University of California, Irvine, California.
Richard EcheverriaDepartment of Radiological Sciences, University of California, Irvine, California.
Wen-Pin ChenChao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California.
Victoria NguyenDepartment of Radiological Sciences, University of California, Irvine, California.
Omar GutierrezDepartment of Radiological Sciences, University of California, Irvine, California.
Sunmin LeeDepartment of Medicine, University of California Irvine, Irvine, California; Coleader of Cancer Control Program for Chao Family Comprehensive Cancer Center.
Michael A HoytChair and Professor of Population Health & Disease Prevention; Department of Population Health and Disease Prevention, University of California Irvine, Irvine, California; Director of the Biobehavioral Shared Resource, UCI Chao Family Comprehensive Cancer Center and the UCI Institute for Interdisciplinary Salivary Bioscience Research.
Argyrios ZiogasChao Family Comprehensive Cancer Center, University of California Irvine, Irvine, California; Department of Medicine, University of California Irvine, Irvine, California.
Tan Q NguyenDirector of Family Medicine Medical Education, Department of Family Medicine, University of California Irvine, Irvine, California.
Hari KeshavaDivision of Thoracic Surgery, Department of Surgery, University of California Irvine, Irvine, California.
Gelareh SadighDirector of Health Services and Comparative Outcome Research; Vice Chair for Faculty Development; Department of Radiological Sciences, University of California, Irvine, California; Associate Editor for JACR. Electronic address: gsadigh@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
NCATS NIH HHS UM1 TR004927NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

backgroundLung cancer screening (LCS) uptake remains low nationally. We evaluated the feasibility and preliminary efficacy of a multilevel intervention to improve LCS uptake in a pilot trial.

methodsEligible patients were 50 to 80 and met 2021 United States Preventive Services Task Force LCS criteria. The Empower LCS intervention included (1) a decision aid; (2) a text reminder to encourage LCS discussion with primary care providers (PCPs); (3) PCP notifications on eligibility and barriers, and (4) financial hardship and health-related social needs support. Screening outcomes (LCS discussions, orders, and completion) at 6 months were assessed using medical records and surveys. Changes in LCS knowledge and health beliefs were assessed with surveys.

resultsIn all, 70 patients enrolled (mean age: 62.5 ± 6.3; 70% male; 1.4% Black, 18.6% Asian, 44.3% White, 35.7% other); 45.7% were Hispanic, and 41% were current smokers. Common LCS barriers included cost concerns (40%, 28 of 70) and fear of finding something wrong (34.3%, 24 of 70). All received the decision aid, text reminder, and PCP alert. Of the patients, 72.9% reported financial hardship or health-related social needs and received support. At 6 months, 71.4% (50 of 70) discussed LCS with their PCP, 51.4% (36 of 70) received low-dose CT orders, and 27.1% (19 of 70) completed screening (52.8% of those with order). Completion exceeded the national average of 16% (P = 0.01). Knowledge and perceived severity changed significantly (knowledge: from 1.91 to 2.67, P = .01; severity: from 16.3 to 18.1, P = .0003). No significant changes were observed in perceived barriers or self-efficacy.

conclusionThe Empower LCS intervention was feasible and improved LCS uptake. However, only half of those with LCS order, completed screening, suggesting the need for enhanced navigation.

Indexed as

Early Detection of CancerLung NeoplasmsPatient ParticipationTomography, X-Ray ComputedAgedAged, 80 and overDecision Support TechniquesFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsRadiation DosageLung cancermultilevel interventionpatient barriersscreening

Identifiers

PMID41241060
PMCPMC12719046

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.