Evidence map›Paper›PMID 41241014›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2026

Controlled delivery of STING agonist and manganese ion in injectable PLGA implants for enhanced cancer immunotherapy.

Swetha Kodamasimham, Helen H Ju, Xingwu Zhou, Yusuf Haggag, Clara Huang, Brianna Ha, Daria Salamevich, Young Seok Cho, Qi Wu, Steven P Schwendeman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Swetha KodamasimhamDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Helen H JuDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Xingwu ZhouDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Yusuf HaggagDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA; Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Clara HuangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Brianna HaDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
Daria SalamevichDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Young Seok ChoDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Qi WuDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Steven P SchwendemanDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: schwende@umich.edu.
James J MoonDepartment of Pharmaceutical Sciences, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: moonjj@umich.edu.

Funding

Restoring the Immunogenicity of Head and Neck CancerR01DE026728 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yu Leo Lei, James J. Moon · 2018 to 2026
$4.3M
Engineered Nano-formulations for STING ActivationR01DE031951 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yu Leo Lei, James J. Moon · 2022 to 2026
$3.1M
New Engineering Strategy for Harnessing Immune System against Head and Neck CancerR01DE030691 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEI, YU LEO, MOON, JAMES J. · 2021 to 2025
$2.9M
Biomaterials for modulating the gut microbiome for immune activationR01CA271799 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI James J. Moon, Deepak Nagrath · 2022 to 2026
$2.7M
Novel nano-vaccine technology for inducing immunity against gliomasR01NS122536 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASTRO, MARIA G, MOON, JAMES J. · 2021 to 2025
$2.6M
Novel biomaterials for IBD treatmentR01DK125087 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAMADA, NOBUHIKO, MOON, JAMES J. · 2020 to 2023
$2.5M
Nanomaterials for eliciting anti-tumor T-cells-Diversity SupplementR01CA210273 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2017 to 2021
$2.2M
NCI NIH HHS R01 CA210273NCI NIH HHS R01 CA271799NIDCR NIH HHS R01 DE026728NIDCR NIH HHS R01 DE030691NIDCR NIH HHS R01 DE031951NIDDK NIH HHS R01 DK125087NINDS NIH HHS R01 NS122536
6 · The paper itself

Abstract

The cGAS-STING pathway plays a central role in innate immune sensing of cancer and represents a promising target for cancer immunotherapy. We previously demonstrated that nutritional metal ions, such as manganese (Mn

Indexed as

Colonic NeoplasmsManganeseMembrane ProteinsNucleotides, CyclicPolylactic Acid-Polyglycolic Acid CopolymerAnimalsCell Line, TumorDelayed-Action PreparationsDrug ImplantsFemaleHumansImmunotherapyMiceMice, Inbred BALB CSTING ProteinDelayed-Action PreparationsDrug ImplantsManganeseMembrane ProteinsNucleotides, CyclicPolylactic Acid-Polyglycolic Acid CopolymerSting1 protein, mouseSTING ProteinCancer immunotherapyControlled releaseImplantsManganesePLGASTING

Identifiers

PMID41241014
PMCPMC12831163

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.