ArticleThe Lancet. Global health2025
Ranking the most efficient human papillomavirus vaccination strategies in low-income and lower-middle income countries: a mathematical modelling analysis.
Article in The Lancet. Global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Cost-effectiveness of single-dose versus two-dose HPV vaccination: a Markov cohort modelling analysis of a Kenya-India LMIC composite.Frontiers in public health · 2026Article
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10 authors.
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Abstract
backgroundOne-dose vaccination and increased vaccine supply provide the opportunity for low-income countries (LICs) and lower-middle-income countries (LMICs) to extend human papillomavirus (HPV) vaccination to populations other than girls aged 9-14 years targeted by routine vaccination. The aim of our study was to use mathematical modelling to identify and rank HPV vaccination strategies according to their efficiency at reducing cervical cancer in LICs and LMICs.
methodsIn this mathematical modelling analysis, we used HPV-ADVISE to model the efficiency of 162 vaccination strategies in 67 LICs and LMICs varying the following parameters: targeted populations (girls and women or gender neutral); age cohorts (routine vaccination at age 9 years or multi-age cohorts up to age 14 years, 20 years, 25 years, 30 years, and 35 years); number of doses (one or two); and vaccination coverage (40-90%), under different one-dose vaccine efficacy and duration assumptions. We measured efficiency using the number of doses needed to prevent one cervical cancer (ie, number needed to vaccinate [NNV]), obtained by dividing the incremental number of doses given by the incremental number of cervical cancers averted over 100 years. We ranked, incrementally, all strategies from most to least efficient.
findingsGlobally, under our base-case assumptions (80% vaccination coverage, non-inferior one-dose vaccine, and unfeasibility of increasing vaccination coverage), the model projects that, following routine vaccination of girls aged 9 years with one dose, the most efficient strategies (efficiency frontier) would be, in order: multi-age cohort vaccination of girls aged 10-14 years with one dose (NNV 48); multi-age cohort vaccination of girls aged 15-20 years with one dose (NNV 64); multi-age cohort vaccination of women aged 21-25 years with two doses (NNV 369); routine and multi-age cohort vaccination of boys aged 9-20 years with one dose (NNV 512); multi-age cohort vaccination of women aged 26-30 years (NNV 640) and 31-35 years (NNV 771) with two doses. Under all scenarios investigated (varying vaccination coverage, one-dose vaccine assumptions, and country characteristics), the model projects that the most efficient strategies would be to vaccinate girls up to age 20 years with one dose. The next most efficient strategies depend on the vaccination coverage that can be achieved and the cervical cancer incidence in a given country.
interpretationOur study suggests that the most efficient vaccination strategy to prevent cervical cancer in LICs and LMICs is to vaccinate girls aged up to 20 years with a single-dose vaccine with high vaccination coverage, before adding boys or providing a second dose to girls. The choice of additional populations to vaccinate will depend on the characteristics and prioritisation goals of a country.
fundingWHO, Canadian Institute of Health Research, and the Gates Foundation.
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