ArticleThe Lancet. Global health2025
Effect of malaria chemoprevention for school-age children across transmission archetypes: a modelling study.
Article in The Lancet. Global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- "We are not sick, so why take medicine?" Community perspectives on barriers, facilitators, and implementation strategies for IPTsc in Ghana.Malaria journal · 2026Article
- Asymptomatic school-age children carry the majority of transmissible Plasmodium falciparum infections.Communications medicine · 2026Article
- Implementation of the intermittent preventive treatment of malaria in school-aged children (IPTsc) in moderate and high endemic areas in Tanzania: a policy brief.EClinicalMedicine · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundIntermittent preventive treatment (IPT) of school-aged children with antimalarial drugs decreases rates of infection, anaemia, and clinical malaria. Since school-aged children are a major transmission reservoir, we estimated the effect of IPT for this group on Plasmodium falciparum transmission to younger children and adults across three epidemiological settings.
methodsWith the use of an established malaria transmission model, we developed three epidemiological archetypes (Sahelian, Central, and Southern African) and estimated the effect of IPT of school-age children across transmission levels (P falciparum parasite rate in children aged 2-10 years [PfPR
findingsWhen long-acting drugs were administered frequently (monthly campaigns with dihydroartemisinin-piperaquine), modelled IPT of school-age children averted 70-90% of cases in school-aged children (up to about 2·0 cases per child per year) and 20-60% of cases in younger children and adults (up to about 0·5 cases per person per year), with greater community benefit at lower transmission levels (PfPR
interpretationOur model suggests that adding IPT of school-age children to current control tools could decrease malaria burden in this group and reduce P falciparum transmission.
fundingUS National Institutes of Health, Doris Duke Clinical Scientist Development Award.
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