Evidence map›Paper›PMID 41240396›Full record

ArticleClinical and translational allergy2025

Key Predictors of Adherence to a Mobile Health App for Managing Chronic Spontaneous Urticaria.

Hugo Viegas, Bernardo Sousa-Pinto, Rafael José Vieira, Aiste Ramanauskaite, Ellen Witte-Händel, Ana Gimenez-Arnau, Carole Guillet, Claudio Alberto Salvador Parisi, Constance Katelaris, Daria Fomina and 49 more

Abstract read
In one paragraph

Article in Clinical and translational allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

59 authors.

Hugo ViegasMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Bernardo Sousa-PintoMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Rafael José VieiraMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0003-1834-3055
Aiste RamanauskaiteInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Ellen Witte-HändelInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Ana Gimenez-ArnauDepartment of Dermatology, Urticaria Center of Reference, and Excellence (UCARE), Hospital del Mar, IMIM, Universitat Pompeu Fabra, Barcelona, Spain.ORCID https://orcid.org/0000-0001-5434-7753
Carole GuilletDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Claudio Alberto Salvador ParisiAdult and Pediatric Allergy Sections of the Italian Hospital of Buenos Aires, Buenos Aires, Argentina.
Constance KatelarisDepartment of Medicine, Campbelltown Hospital and Western Sydney University, Sydney, New South Wales, Australia.
Daria FominaMoscow City Research and Practical Center of Allergology and Immunology, Clinical Hospital No 52, Moscow Healthcare Department, Russia Angioedema/Urticaria Center of Reference and Excellence (ACARE, UCARE), Moscow, Russia.
Désirée Larenas-LinnemannCenter of Excellence in Asthma and Allergy Larenas Hospital Médica Sur, Mexico City, Mexico.ORCID https://orcid.org/0000-0002-5713-5331
Jorge SánchezGroup of Clinical and Experimental Allergy, Hospital 'Alma Mater de Antioquia', University of Antioquia, Medellín, Colombia.ORCID https://orcid.org/0000-0001-6341-783X
Elizabeth GarciaFaculty of Medicine, Universidad de los Andes, Allergy Section, Fundación Santa Fe de Bogotá, UNIMEQ ORL, Bogotá, Colombia.
Hermenio LimaLEADER Research Inc. and Division of Allergy and Clinic Immunology (UCARE), Medicine Department, McMaster University, Hamilton, Ontario, Canada.
Igor KaidashevPoltava State Medical University, Poltava, Ukraine.
Iman NasrDepartment of Clinical Immunology and Allergy, Royal Hospital, Muscat, Oman.
Isabel Ogueta CanalesDepartment of Dermatology, Faculty of Medicine, Pontifical Catholic University of Chile, Santiago, Chile.
Ivan Cherrez-OjedaInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1610-239X
Jean BousquetInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-4061-4766
Jonathan A BernsteinDivision of Rheumatology, Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-3476-1196
Jonny PeterACARE Centre, Division of Allergy and Clinical Immunology, Department of Medicine, Groote Schuur Hospital, University of Cape Town Lung Institute, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-2658-0723
Jose Ignacio Larco SousaDepartment of Allergy, UCARE, Clinica San Felipe, Lima, Peru.
Kanokvalai KulthananDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Karsten WellerInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Kiran GodseDepartment of Dermatology, Dr D Y Patil Medical College and Hospital, Navi Mumbai, India.
Krzysztof RutkowskiUrticaria Clinic, St John's Institute of Dermatology, Guy's and St Thomas' Hospital, London, UK.
Lasma LapinaAllergic Diseases Diagnosis and Treatment Center, Riga Stradins University, Pauls Stradins Clinical University Hospital, Riga, Latvia.ORCID https://orcid.org/0000-0002-2242-5232
Laurence BouilletFrench National Reference Center for Angioedema (CREAK), Internal Medicine Department, Grenoble University Hospital, La Tronche, France.
Luis Felipe EnsinaDivision of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of Sao Paulo, Sao Paulo, Brazil.
Margarida GonçaloDermatology, Faculty of Medicine, University of Coimbra and University Hospital, Coimbra Local Health Unit, Coimbra, Portugal.ORCID https://orcid.org/0000-0001-6842-1360
Maria StaevskaMedical University of Sofia, Sofia, Bulgaria.
Mariam Ali Yousuf Al-NesfAllergy and Immunology Section, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Markus MagerlInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0001-9218-5468
Martin MetzInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-4070-9976
Martijn van DoornDepartment of Dermatology, UCARE, Erasmus MC, Rotterdam, the Netherlands.
Mary Anne CastorDepartment of Pediatrics, University of the Philippines Manila-Philippine General Hospital, Manila, Philippines.
Maryam KhoshkhuiAllergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Michael MakrisAllergy Unit, 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University General Hospital "Attikon", Athens, Greece.
Michihiro HideDepartment of Dermatology, Hiroshima City Hiroshima Citizens Hospital, Department of Dermatology, Hiroshima University, Hiroshima, Japan.
Mohamad AbuzakoukAllergy & Immunology Department, Respiratory Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Mona Al-AhmadFaculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Murat TürkDivision of Allergy and Clinical Immunology, Erciyes University School of Medicine, Kayseri, Türkiye.
Natasa Teovska MitrevskaReMedika General Hospital, Skopje, North Macedonia.
Niall ConlonSchool of Medicine, Trinity College Dublin, St James's Hospital Dublin, Dublin, Ireland.
Nicole NojarovInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Pavel KolkhirInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0001-5380-8132
Philip LiUniversity of Hong Kong, Hong Kong, Hong Kong.
Ramzy Mohammed AliAllergy and Immunology Section, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Rand ArnaoutDepartment of Dermatology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Riccardo AseroAmbulatorio di Allergologia, Clinica San Carlo, Milan, Italy.
Sabine AltrichterInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0001-9955-385X
Simon Francis ThomsenDepartment of Biomedical Sciences, Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4838-300X
Young-Min YeDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0002-7517-1715
Zenon BrzozaDivision of Allergology, Department of Internal Diseases, Institute of Medical Sciences, University of Opole, Opole, Poland.
Zuotao ZhaoDepartment of Dermatology and Venerology, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Diseases, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Peking University First Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-9595-6050
Torsten ZuberbierInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1466-8875
Frank SiebenhaarInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-4532-1644
Emek KocatürkInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sophia NeisingerInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0009-0000-5967-4809

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMobile health technologies may improve the management of chronic diseases, such as chronic spontaneous urticaria. However, effectiveness of mHealth tools largely depends on patient adherence, which can be influenced by various demographic, clinical, behavioural, psychosocial factors, and apps characteristics (appealing and simplicity of use). Understanding these adherence patterns is crucial for optimizing mHealth interventions. In this study, we aimed to assess adherence patterns associated to the use of CRUSE, a mHealth app designed for patients with CSU.

methodsWe assessed users of the CRUSE app with self-reported CSU or suggested by a physician. For each user, we evaluated the number of days they completed the CRUSE daily monitoring questionnaire (app adherence) within the first 3 months after installation. We constructed univariable and multivariable ordered beta regression models to identify predictors of 3-month adherence to the app.

resultsWe analysed data from 2085 patients (66,114 days). Median adherence to the CRUSE app was of 22 days (24.4% of 90 days). In multivariable regression models, the variables more strongly associated with increased adherence to CRUSE included age (average increase = 0.16 percent points [pp] per additional year; 95% credible interval [CrI] = 0.08; 0.23 pp), male sex (average difference = 4.24 pp; 95% CrI = 1.77; 6.39 pp), being from a European country (average difference = 2.66 pp; 95% CrI = 0.59; 5.19 pp), and using monoclonal antibodies (average difference = 4.60 pp; 95% CrI = 2.26; 6.65 pp).

conclusionsOur findings suggest that age, male sex, residence in Europe, and the use of monoclonal antibodies are significant factors associated with increased adherence to the CRUSE app. These insights may help identify patient subgroups who would benefit most from mHealth support in managing CSU.

Indexed as

adherencechronic spontaneous urticariamHealth

Identifiers

PMID41240396
PMCPMC12619656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.