Evidence map›Paper›PMID 41240313›Full record

ReviewSub-cellular biochemistry2026

Biomolecular Condensates in and Around the ER-Golgi Interface.

Miguel Ruiz, Savannah M Bogus, Andreas M Ernst

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Miguel RuizDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA. mir047@ucsd.edu.
Savannah M BogusDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA.
Andreas M ErnstDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA, USA. aernst@ucsd.edu.

Funding

Morphological Determinants of Intracellular Membrane CompartmentsR35GM142433 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andreas Max Ernst · 2021 to 2026
$2.2M
In situ cryo-EM of protein condensates in the early secretory pathway of neuronsR21DA061421 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ERNST, ANDREAS MAX, VILLA, ELIZABETH · 2024 to 2025
$437k
NIDA NIH HHS R21 DA061421NIGMS NIH HHS R35 GM142433
6 · The paper itself

Abstract

Biomolecular condensates represent a new paradigm of cytoplasmic organization. In recent years, an increasing amount of evidence suggests that protein condensates can directly impact the morphology and function of membrane compartments. The early secretory pathway, which comprises the ER and Golgi compartments, is emerging as a hotspot for biomolecular condensates. In this chapter, we discuss recent reports suggesting diverse roles for condensates in cargo sorting, regulating membrane traffic, and shaping organelle morphology. This promotes a view in which biomolecular condensates may significantly contribute to defining the anatomy and specific functions of the Golgi and its surrounding membranes.

Indexed as

Biomolecular CondensatesEndoplasmic ReticulumGolgi ApparatusAnimalsHumansProtein TransportCondensatesEarly secretory pathwayERER exit sites (ERESs)ER-Golgi interfaceGolgi matrixLiquid-liquid phase separationSelf-organization

Identifiers

PMID41240313

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.