The Impact of Golgi Organization on Cell Cycle and Cancer Development.

The Golgi complex plays a pivotal role in the secretory pathway, cell signaling, and cytoskeleton organization. In mammalian cells, it is organized as a ribbon-like structure that can undergo dynamic reorganizations, which are crucial for various cellular processes, including mitosis and cell migration. During mitosis, the Golgi complex is subjected to a tightly regulated disassembly process, essential for proper cell division, while its reformation is critical for inheritance by daughter cells. Disruption of Golgi organization has been linked to pathological conditions, including cancer, as altered organization and function can contribute to tumor progression by impacting glycosylation, cell polarity, and extracellular matrix remodeling. This chapter explores the molecular mechanisms regulating Golgi disassembly during the cell cycle and its involvement in ensuring proper cell division. Additionally, we discuss the emerging understanding of the potential role of modifications of the Golgi organization in tumor development and metastasis. Collectively, the findings presented in this chapter underscore the physiological significance of the Golgi ribbon structure and the pathological implications of its alterations in cancer progression, which could offer novel therapeutic opportunities for cancer treatment.