ArticleForensic science, medicine, and pathology2026
Histological artifacts induced by the contrast agent in Multi-Phase Post-Mortem CT Angiography (MPMCTA): Part I - Normal Tissues.
Article in Forensic science, medicine, and pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mapping two decades of forensic virtopsy: a comprehensive bibliometric analysis (2006-2025).International journal of legal medicine · 2026Review
- Multiphase post-mortem CT angiography (MPMCTA) in sudden natural death: diagnostic contribution and workflow impact in a forensic autopsy series.Forensic science, medicine, and pathology · 2026Article
- Histological artifacts induced by the contrast agent in multi-phase post-mortem CT angiography (MPMCTA): Part II - Pathological tissues.Forensic science, medicine, and pathology · 2026Article
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Authors and funding
10 authors.
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Abstract
introductionMultiphase postmortem computed tomographic angiography (MPMCTA) is a technique that provides comprehensive visualization of the cardiovascular system by injection of a contrast agent into the cadaver. Our aim is to systematically describe the histo-morphological changes and artifacts induced by the injection of the mixture of contrast agents (Angiofil® and paraffin oil) used for MPMCTA. MATERIALS AND
methodsHistological specimens taken from 37 cases undergoing MPMCTA and autopsy were analyzed. Histological sections were analyzed using a Semi-motorized Olympus BX53 microscope associated with Olympus DP21 camera for images acquisition, in consecutive reading sessions by three forensic pathologists with experience in the field of histopathology for 20 years.
resultsA total of 278 histological samples was included in the study. Different types of artifacts were encountered, which can be grouped into four main categories: the presence of optical empty spaces; the compression of surrounding structures; hyperaemia of small vessels and capillaries; vessel dilation.
conclusionsPostmortem angiography is a valuable method for visualizing blood vessels. However, the use of contrast media can introduce histological artifacts. This potential impact should be carefully considered when deciding whether to perform the procedure.
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