Evidence map›Paper›PMID 41240283›Full record

Observational studyGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026

Outcomes of endoscopic submucosal dissection for locally recurrent early gastric cancer after endoscopic resection: analysis of a multicenter prospective cohort study.

Takuma Hiramatsu, Naomi Kakushima, Haruhisa Suzuki, Kohei Takizawa, Toshiaki Hirasawa, Yoji Takeuchi, Kenji Ishido, Shu Hoteya, Tomonori Yano, Shinji Tanaka and 17 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Takuma HiramatsuDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Naomi KakushimaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Haruhisa SuzukiDivision of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan. suzuki.haruhisa@nihon-u.ac.jp.
Kohei TakizawaDivision of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Toshiaki HirasawaDepartment of Gastroenterology, Cancer Institute Hospital, Tokyo, Japan.
Yoji TakeuchiDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Kenji IshidoDepartment of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.
Shu HoteyaDepartment of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
Tomonori YanoDepartment of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.
Shinji TanakaDepartment of Gastroenterology, JA Onomichi General Hospital, Onomichi-City, Hiroshima, Japan.
Yosuke ToyaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan.
Masahiro NakagawaDepartment of Endoscopy, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Tetsuya YoshizakiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Naohiro YoshidaDepartment of Gastroenterology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Kingo HirasawaDivision of Endoscopy, Yokohama City University Medical Center, Yokohama, Japan.
Mitsuru MatsudaDepartment of Gastroenterology, Toyama Prefectural Central Hospital, Toyama, Japan.
Hironori YamamotoDepartment of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Chizu YokoiDepartment of Gastroenterology, National Center for Global Health and Medicine, Tokyo, Japan.
Ken OhnitaDepartment of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan.
Yasuhiro HisanagaDepartment of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan.
Taichi ShimazuDivision of Behavioral Sciences, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Hiroyuki OnoDivision of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Satoshi TanabeDepartment of Gastroenterology, Ebina General Hospital, Ebina, Japan.
Hitoshi KondoDepartment of Gastroenterology, Tonan Hospital, Sapporo, Japan.
Hiroyasu IishiDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Motoki NinomiyaDigestive disease center, Yuuai Medical Center, Okinawa, Japan.
Ichiro OdaEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to reveal the outcomes of endoscopic resection (ER) for locally recurrent early gastric cancer (LRGC) after ER using the data obtained in a Japanese multicenter prospective cohort study of ER for early gastric cancer (EGC) using Web registry (J-WEB/EGC).

methodsShort-term and long-term outcomes were compared between 125 LRGCs (119 patients) and 9387 primary EGCs of naive stomach (8455 patients) enrolled in this study at 41 centers between July 2010 and June 2012. We calculated 5-year overall survival rates (OS) and disease-specific survival rates (DSS) for LRGC, divided ERs into curative and noncurative resections, and calculated hazard ratios (HR) for all-cause mortality with Cox regression analysis.

resultsFor LRGCs and primary EGCs, median resection times were 100 and 77 min (p<0.0001), en-bloc resection rates were 97.6% and 99.5% (p<0.05), and R0 resection rates were 86.4% and 93.3% (p<0.05), respectively. There were no significant differences for adverse events between LRGC and primary EGC. Five-year OS and DSS for LRGC cases were 89.9% and 100%. Compared to curatively resected primary EGC cases, HR for all-cause mortality of curatively resected LRGC, noncuratively resected primary EGC and noncuratively resected LRGC cases were 0.58 (95% CI 0.24-1.41), 1.46 (1.25-1.7) and 3.02 (1.43-6.36), respectively.

conclusionsA curative ER for LRGC offers the same long-term prognosis as primary EGC. ER for LRGC can offer a secure and radical treatment.

Indexed as

Endoscopic Mucosal ResectionNeoplasm Recurrence, LocalStomach NeoplasmsAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansJapanMaleMiddle AgedPrognosisProspective StudiesSurvival RateTreatment OutcomeNeoplasm recurrenceStomach neoplasmsStomach ulcer

Identifiers

PMID41240283

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.