Evidence map›Paper›PMID 41240234›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

Impact of shortages of amoxicillin and amoxicillin/clavulanate on the outcome of bacterial sinusitis in adults: a French retrospective, single-centre study.

Sandra Devatine, Clara Maubaret, Florian Chatelet, Anne Lise Munier, Benjamin Verillaud, Noémie Leclerc Du Sablon, David Lebeaux, Sarah Atallah

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Sandra DevatineDépartement de Maladies Infectieuses et Tropicales, AP-HP, Groupe hospitalier Saint Louis-Lariboisière-Fernand-Widal, 2 rue Ambroise Paré, Paris, 75010, France. sandra.devatine@aphp.fr.
Clara MaubaretLaboratoire de bactériologie, AP-HP, Groupe hospitalier Saint Louis-Lariboisière- Fernand-Widal, Université Paris Cité, Paris, France.
Florian ChateletAPHP, ENT and head and neck surgery Department, Paris city University, Lariboisière Hospital, 2 rue Ambroise Paré, Paris, 75010, France.
Anne Lise MunierDépartement de Maladies Infectieuses et Tropicales, AP-HP, Groupe hospitalier Saint Louis-Lariboisière-Fernand-Widal, 2 rue Ambroise Paré, Paris, 75010, France.
Benjamin VerillaudAPHP, ENT and head and neck surgery Department, Paris city University, Lariboisière Hospital, 2 rue Ambroise Paré, Paris, 75010, France.
Noémie Leclerc Du SablonService de Biostatistique et Information Médicale, AP-HP. Nord, Hôpitaux Lariboisière - Fernand-Widal, Université Paris Cité, Paris, France.
David LebeauxDépartement de Maladies Infectieuses et Tropicales, AP-HP, Groupe hospitalier Saint Louis-Lariboisière-Fernand-Widal, 2 rue Ambroise Paré, Paris, 75010, France.
Sarah AtallahAPHP, ENT and head and neck surgery Department, Paris city University, Lariboisière Hospital, 2 rue Ambroise Paré, Paris, 75010, France. sarah.atallah@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesRecent shortages of amoxicillin and amoxicillin/clavulanate in France have raised concerns about a possible impact on the management and outcome of acute sinusitis. We therefore assessed the rates of complicated sinusitis occurring during two time periods, one with and one without antibiotic shortages.

methodsWe reviewed cases of sinusitis from two periods: December-February 2018-19 and 2019-20 (no antibiotic shortages) and December-February 2021-22 and 2022-23 (shortages of amoxicillin and amoxicillin/clavulanate). We included all patients over 15 years of age who had been treated in the hospital's ear, nose and throat department of Lariboisiere hospital for sinusitis. The primary outcome was the rate of complicated sinusitis among the total number of cases of sinusitis treated at Lariboisière hospital during the two study periods.

resultsOne hundred and forty-two patients were treated for sinusitis during the study periods: 60 during the no-shortage period and 82 during the shortage period. The rate of complicated sinusitis was significantly higher during the shortage period (23/82, 28%) than during the no-shortage period (3/60, 5%) (OR 7.32, CI [2.04-40.15], p=0.0003). The use of alternative antibiotics prior to attendance was independently associated with an increased risk of complications (OR 7.88, CI [1.58-77.87], p=0.004). The presence of oral streptococci was also associated with complications, suggesting a correlation between microbial patterns and antibiotic shortages.

conclusionsShortages of first-line antibiotics for sinusitis was associated with an increased rate of complications, highlighting the need to explore alternative treatments and reinforce public health actions to anticipate shortages.

Indexed as

AmoxicillinAmoxicillin-Potassium Clavulanate CombinationAnti-Bacterial AgentsBacterial InfectionsSinusitisAdolescentAdultAgedFemaleFranceHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeYoung AdultAmoxicillinAmoxicillin-Potassium Clavulanate CombinationAnti-Bacterial AgentsAntibiotic policyAntibiotic shortageCommunity-acquired infectionsENT infectionsSinusitis

Identifiers

PMID41240234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.