ArticleMolecular and cellular biochemistry2026
GNB2 promotes breast cancer progression by up-regulating HSPA5/GPX4 and inhibiting ferroptosis.
Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Role of Se-Containing Glutathione Peroxidases and Thioredoxin Reductases in Oncogenesis: Expression Paradoxes and Therapeutic Prospects.Antioxidants (Basel, Switzerland) · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
G protein subunit beta 2 (GNB2) is a potential biomarker identified recently in human cancers. However, the specific role and its underlying mechanism in breast cancer (BRCA) remain unclear. Expression levels of GNB2 were examined in human BRCA tissues and cells by real-time quantitative PCR (qPCR), immunohistochemistry (IHC) and Western blot. Biological functions of GNB2 were determined by a series of in vitro experiments (CCK-8, colony formation assay, Transwell and wound healing) and in vivo ones (subcutaneous transplantation tumor and pulmonary metastasis model). Mechanism of GNB2 in BRCA was explored by co-immunoprecipitation (Co-IP), qPCR, Western blot, flow cytometry and some rescue experiments. Increased expression of GNB2 was found in BRCA, which indicated poorer clinical prognosis of the patients. The over-expression of GNB2 increased proliferation, migration of BRCA cells, while it decreased the intracellular contents of reactive oxygen species (ROS), Fe
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