ArticleJournal of gastrointestinal cancer2025
Impact of Abdominal Aortic Calcification on Long-Term Outcome after Gastric Cancer Surgery: a Retrospective Study.
Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study examined the impact of abdominal aortic calcification, a known risk factor for cardiovascular disease, on the prognosis of patients undergoing radical surgery for gastric cancer.
methodsThe effects of abdominal aortic calcification on clinical outcomes, prognosis, and recurrence patterns were analyzed in 516 patients who underwent radical surgery for gastric cancer between 2010 and 2017.
resultsAfter propensity score matching, patients with higher abdominal aortic calcification had significantly poorer overall survival (OS; P = 0.020), disease specific survival (DSS; P = 0.013), and recurrence-free survival (RFS; P = 0.017) than those with lower calcification levels. Multivariate Cox regression analysis identified a higher degree of abdominal aortic calcification as an independent risk factor for poor OS (hazard ratio, 2.57; 95% confidence interval, 1.56-4.22; P < 0.001), DSS (hazard ratio, 4.32; 95% confidence interval, 1.84-10.12; P < 0.001) and RFS (hazard ratio, 2.63; 95% confidence interval, 1.60-4.33; P < 0.001). High abdominal aortic calcification was also a risk factor for peritoneal dissemination recurrence in gastric cancer.
conclusionA high degree of abdominal aortic calcification was linked to poor prognosis and might increase peritoneal dissemination recurrence following curative resection for gastric cancer. Thus, abdominal aortic calcification may serve as a novel clinical tool for predicting the prognosis of patients with gastric cancer.
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