Evidence map›Paper›PMID 41240201›Full record

ArticleJournal of clinical immunology2025

S100A4 Induces Neutrophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps via TLR4 Pathway.

Yanyi Tu, Chunhao Li, Tao Li, Jing Liu, Linghui Meng, Shengyang Liu, Ping Li, Yuzhu Wan, Aiping Chen, Li Shi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yanyi Tu *Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Chunhao Li *Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Tao LiDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Jing LiuDepartment of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Linghui MengDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Shengyang LiuDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Ping LiDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Yuzhu WanDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Aiping ChenDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China.
Li ShiDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, No. 4 Duanxing West Road, Jinan, 250000, Shandong, China. shili126@sina.com.
De-Yun WangDepartment of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore. entwdy@nus.edu.sg.

Funding

National Natural Science Foundation of China 82371117Natural Science Foundation of Shandong Province ZR2022QH336
6 · The paper itself

Abstract

backgroundTreating neutrophilic inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenge. Managing excessive infiltration and activation of neutrophils in tissues is important for improving CRSwNP outcomes. S100A4, a calcium-binding protein, regulates cell migration, chemotaxis and tissue fibrosis. In this study, we sought to examine the role of S100A4 in neutrophilic inflammation in CRSwNP and its involvement in TLR4 signaling.

methodsQuantitative RT-PCR and immunofluorescence were used to analyze the expression and cellular distribution of S100A4 in sinonasal mucosa. Primary human nasal epithelial cells (hNECs) were cultured and treated with S100A4 to assess cytokine and chemokine production. Additionally, we employed TLR4 inhibitor (TAK-242) to investigate whether S100A4 exert this effect via TLR4 pathway.

resultsWe found increased levels of S100A4 mRNA and S100A4

conclusionS100A4 is elevated in neutrophilic CRSwNP and exerts its pro-inflammatory effect on nasal epithelial cells via TLR4 signaling cascade.

Indexed as

InflammationNasal PolypsNeutrophilsRhinitisS100 Calcium-Binding Protein A4SinusitisToll-Like Receptor 4AdultCells, CulturedChronic DiseaseCytokinesFemaleHumansMaleMiddle AgedNasal MucosaCytokinesS100A4 protein, humanS100 Calcium-Binding Protein A4TLR4 protein, humanToll-Like Receptor 4EosinophilNasal polypsNeutrophilS100A4TLR4

Identifiers

PMID41240201
PMCPMC12619731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.