Evidence map›Paper›PMID 41240172›Full record

ArticleVeterinary research communications2025

Protective effects of chlorogenic acid on hepatic injury in piglets challenged with lipopolysaccharide: a preliminary study.

Kang Cheng, Yuanqing Ma, Jinxiu Yao, Chenyu Chang, Yao Meng, Wenjing Wang, Hongyue Zhao, Jinrong Wang, Yong Zhang

Abstract read
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In one paragraph

Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kang ChengSchool of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China. chengkang68@126.com.
Yuanqing MaSchool of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China.
Jinxiu YaoSchool of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China.
Chenyu ChangSchool of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China.
Yao MengSchool of International Education, Henan University of Technology, Zhengzhou, 450001, China.
Wenjing WangSchool of International Education, Henan University of Technology, Zhengzhou, 450001, China.
Hongyue ZhaoSchool of International Education, Henan University of Technology, Zhengzhou, 450001, China.
Jinrong WangSchool of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China.
Yong ZhangSchool of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China.

Funding

National Natural Science Foundation of China 32202722Project of Supporting Young Backbone Teachers of Henan University of Technology of China 21421254Start-up Fund Project for High-level Talent Scientific Research of Henan University of Technology of China 2021BS072the Innovation and Entrepreneurship Training Program for College Students in Henan University of Technology of China 202510463096
6 · The paper itself

Abstract

The liver of early weaned piglets is one of the most vulnerable organs to immunological stress. This study investigated the protective effects of chlorogenic acid (CGA) on the liver of weaned piglets subjected to immunological stress induced by lipopolysaccharide (LPS). The weaned piglets were fed with 1 g CGA/kg diet for 21 days prior to an i.p. injection of 100 µg LPS/kg body weight administration. The results showed that the LPS increased serum alanine aminotransferase activity and liver caspase 3 mRNA expression, which were reversed by CGA supplementation. CGA normalized hepatic interleukin (IL) 18 and IL1β at both the protein expression and mRNA abundance, myeloperoxidase activity and p65 mRNA expression in LPS-administrated piglets. Dietary CGA supplementation increased hepatic ATP, complex III and complex I contents in the LPS-challenged piglets. The upregulated hepatic optineurin and BCL2 interacting protein 3 like mRNA levels in the LPS-challenged piglets were normalized to control values when supplementing CGA. These data represent preliminary evidence that CGA attenuates hepatic injury, inflammation, and mitochondrial dysfunction in piglets challenged with LPS, indicating CGA could be a potential natural agent for alleviating liver injury and immunological stress in weaned piglets.

Indexed as

Chemical and Drug Induced Liver InjuryChlorogenic AcidLipopolysaccharidesLiverProtective AgentsSwine DiseasesAnimalsDietDietary SupplementsMaleSwineChlorogenic AcidLipopolysaccharidesProtective AgentsChlorogenic acidInflammationLiver injuryMitochondrial functionPiglets

Identifiers

PMID41240172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.