ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026
Autophagy-dependent cell death and immune responses induced by heteroleptic copper(II), manganese(II), and silver(I) complexes containing dicarboxylate and 1,10-phenanthroline ligands: novel insights from in vitro and in vivo models.
Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Context-dependent ATP7 Interactions with Parkinson's Disease-associated Genes Modulate Copper Homeostasis Phenotypes.bioRxiv : the preprint server for biology · 2026Article
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Abstract
Autophagy is a process that breaks down unwanted cellular components to maintain homeostasis. While it is defined as a 'self-protection' process, a disruption of autophagic mechanisms can lead to cellular death. Autophagy is interconnected with many other cellular processes including innate and adaptive immunity and can therefore have therapeutic potential as it can be modulated to control immune and other cellular responses. We therefore postulated the potential of our Cu(II), Mn(II) and Ag(I) complexes coordinated with 1,10-phenanthroline to interfere with the autophagy process and to induce an immune-response. Herein, we evaluated the ability of a series of heteroleptic complexes, [Cu
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